NF-[kappa]B promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells
The transcription factor NF-κB is constitutively active in pancreatic adenocarcinoma. Here we explore the contribution of NF-κB to the malignant phenotype of pancreatic cancer cells in addition to its anti-apoptotic role. Block of NF-κB signalling by non-destructible IκBα rendered cells resistant to...
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| Veröffentlicht in: | Cancer letters 2010-09, Vol.295 (2), p.214 |
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| creator | Maier, Harald J Schmidt-Straßburger, Uta Huber, Margit A Wiedemann, Eva M Beug, Hartmut Wirth, Thomas |
| description | The transcription factor NF-κB is constitutively active in pancreatic adenocarcinoma. Here we explore the contribution of NF-κB to the malignant phenotype of pancreatic cancer cells in addition to its anti-apoptotic role. Block of NF-κB signalling by non-destructible IκBα rendered cells resistant to TGF-β-induced epithelial-mesenchymal transition (EMT). In contrast, NF-κB activation by TNF-α or expression of constitutively active IKK2 induced an EMT-phenotype with up-regulation of vimentin and ZEB1, and down-regulation of E-cadherin. EMT could also be induced in cells with defective TGF-β signalling. Functional assays demonstrated reduced or strongly enhanced migration and invasion upon NF-κB inhibition or activation, respectively. |
| doi_str_mv | 10.1016/j.canlet.2010.03.003 |
| format | Article |
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Here we explore the contribution of NF-κB to the malignant phenotype of pancreatic cancer cells in addition to its anti-apoptotic role. Block of NF-κB signalling by non-destructible IκBα rendered cells resistant to TGF-β-induced epithelial-mesenchymal transition (EMT). In contrast, NF-κB activation by TNF-α or expression of constitutively active IKK2 induced an EMT-phenotype with up-regulation of vimentin and ZEB1, and down-regulation of E-cadherin. EMT could also be induced in cells with defective TGF-β signalling. 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| ispartof | Cancer letters, 2010-09, Vol.295 (2), p.214 |
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| subjects | Apoptosis Cell growth Colleges & universities Deoxyribonucleic acid DNA Genes Kinases Medical prognosis Pancreas Pancreatic cancer Proteins Tumors |
| title | NF-[kappa]B promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells |
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