Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells

Abstract The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated...

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Veröffentlicht in:	Cancer letters 2007-11, Vol.257 (2), p.165-171
Hauptverfasser:	Gatouillat, Grégory, Odot, Johann, Balasse, Emilie, Nicolau, Claude, Tosi, Pierre-François, Hickman, David T, López-Deber, María Pilar, Madoulet, Claudie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - pharmacology Antibodies - administration & dosage Antibodies - immunology Antibodies - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry ATP-Binding Cassette, Sub-Family B, Member 1 - immunology ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Blotting, Western Cancer Cell Line, Tumor Cell Survival - drug effects Cholesterol Dilution Dimensional analysis Doxorubicin - metabolism Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Resistance, Bacterial Female Flow Cytometry Hematology, Oncology and Palliative Medicine Hypotheses Immunization Immunization - methods Liposomes Liposomes - chemistry Mice Mice, Inbred Strains Molecular Sequence Data Molecular weight Multidrug resistance Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Neoplasms, Experimental - prevention & control P-Glycoprotein Pegylated peptides Peptides Peptides - chemistry Peptides - immunology Polyethylene Glycols - chemistry Proteins Studies Survival Analysis Tumors Vaccines, Subunit - administration & dosage Vaccines, Subunit - chemistry Vaccines, Subunit - immunology
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