Cytogenetic effects in children treated with methylphenidate
In recent years there has been a surge in methylphenidate (Ritalin) use for treatment of attention deficit/hyperactivity disorder (ADHD) in children. However, there is a paucity of information on whether this drug poses any potential health risks, such as mutagenicity or carcinogenicity, for humans....
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| Veröffentlicht in: | Cancer letters 2005-12, Vol.230 (2), p.284-291 |
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| container_title | Cancer letters |
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| creator | El-Zein, Randa A. Abdel-Rahman, Sherif Z. Hay, Matthew J. Lopez, Mirtha S. Bondy, Melissa L. Morris, Debra L. Legator, Marvin S. |
| description | In recent years there has been a surge in methylphenidate (Ritalin) use for treatment of attention deficit/hyperactivity disorder (ADHD) in children. However, there is a paucity of information on whether this drug poses any potential health risks, such as mutagenicity or carcinogenicity, for humans. To address this issue, we investigated whether this central nervous system stimulant produces cytogenetic abnormalities in pediatric patients at therapeutic levels. In a population composed of twelve children treated with therapeutic doses of methylphenidate, we analyzed three cytogenetic endpoints in peripheral blood lymphocytes obtained before and three months after initiation of treatment with this drug. In all participants, treatment induced a significant 3, 4.3 and 2.4-fold increase in chromosome aberrations, sister chromatid exchanges and micronuclei frequencies, respectively (
P=0.000 in all cases). These findings warrant further investigations of the possible health effects of methylphenidate in humans, especially in view of the well-documented relationship between elevated frequencies of chromosome aberrations and increased cancer risk. |
| doi_str_mv | 10.1016/j.canlet.2005.01.003 |
| format | Article |
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P=0.000 in all cases). These findings warrant further investigations of the possible health effects of methylphenidate in humans, especially in view of the well-documented relationship between elevated frequencies of chromosome aberrations and increased cancer risk.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2005.01.003</identifier><identifier>PMID: 16297714</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>ADHD ; Attention Deficit Disorder with Hyperactivity - drug therapy ; Attention deficit hyperactivity disorder ; Central Nervous System Stimulants - adverse effects ; Central Nervous System Stimulants - therapeutic use ; Child ; Child, Preschool ; Children ; Chromosomal aberrations ; Chromosome Aberrations - chemically induced ; Chromosomes ; Female ; Genotoxicity ; Humans ; Hyperactivity ; Lymphocytes - drug effects ; Male ; Methylphenidate ; Methylphenidate - adverse effects ; Methylphenidate - therapeutic use ; Micronuclei, Chromosome-Defective - chemically induced ; Mutagenicity Tests ; Sister Chromatid Exchange ; Studies</subject><ispartof>Cancer letters, 2005-12, Vol.230 (2), p.284-291</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Dec 18, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-fb40a0b913240009fcaede0a216f58d2cfab6cf7853d88a3e5c0c2cd48ab17b33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2005.01.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16297714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Zein, Randa A.</creatorcontrib><creatorcontrib>Abdel-Rahman, Sherif Z.</creatorcontrib><creatorcontrib>Hay, Matthew J.</creatorcontrib><creatorcontrib>Lopez, Mirtha S.</creatorcontrib><creatorcontrib>Bondy, Melissa L.</creatorcontrib><creatorcontrib>Morris, Debra L.</creatorcontrib><creatorcontrib>Legator, Marvin S.</creatorcontrib><title>Cytogenetic effects in children treated with methylphenidate</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>In recent years there has been a surge in methylphenidate (Ritalin) use for treatment of attention deficit/hyperactivity disorder (ADHD) in children. However, there is a paucity of information on whether this drug poses any potential health risks, such as mutagenicity or carcinogenicity, for humans. To address this issue, we investigated whether this central nervous system stimulant produces cytogenetic abnormalities in pediatric patients at therapeutic levels. In a population composed of twelve children treated with therapeutic doses of methylphenidate, we analyzed three cytogenetic endpoints in peripheral blood lymphocytes obtained before and three months after initiation of treatment with this drug. In all participants, treatment induced a significant 3, 4.3 and 2.4-fold increase in chromosome aberrations, sister chromatid exchanges and micronuclei frequencies, respectively (
P=0.000 in all cases). These findings warrant further investigations of the possible health effects of methylphenidate in humans, especially in view of the well-documented relationship between elevated frequencies of chromosome aberrations and increased cancer risk.</description><subject>ADHD</subject><subject>Attention Deficit Disorder with Hyperactivity - drug therapy</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Central Nervous System Stimulants - adverse effects</subject><subject>Central Nervous System Stimulants - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chromosomal aberrations</subject><subject>Chromosome Aberrations - chemically induced</subject><subject>Chromosomes</subject><subject>Female</subject><subject>Genotoxicity</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Lymphocytes - drug effects</subject><subject>Male</subject><subject>Methylphenidate</subject><subject>Methylphenidate - adverse effects</subject><subject>Methylphenidate - therapeutic use</subject><subject>Micronuclei, Chromosome-Defective - chemically induced</subject><subject>Mutagenicity Tests</subject><subject>Sister Chromatid Exchange</subject><subject>Studies</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk7_gUjB69aTJm1TEEGGXzDwRq9DmpzYlK2daabs3xvpwDuvDhye93w8hFxSyCjQ8qbLtOrXGLIcoMiAZgDsiMypqPK0qgUckzkw4CkTrJiRs3HsIIK8Kk7JjJZ5XVWUz8ntch-GD-wxOJ2gtajDmLg-0a1bG499EjyqgCb5dqFNNhja_XrbYu9M7J6TE6vWI14c6oK8Pz68LZ_T1evTy_J-lWomREhtw0FBU1OW83hDbbVCg6ByWtpCmFxb1ZTaVqJgRgjFsNCgc224UA2tGsYW5Hqau_XD5w7HILth5_u4UtICClblnPFI8YnSfhhHj1Zuvdsov5cU5K8y2clJmfxVJoHKqCzGrg7Dd80GzV_o4CgCdxOA8cUvh16O2mGv0TgfdUkzuP83_AC14H7s</recordid><startdate>20051218</startdate><enddate>20051218</enddate><creator>El-Zein, Randa A.</creator><creator>Abdel-Rahman, Sherif Z.</creator><creator>Hay, Matthew J.</creator><creator>Lopez, Mirtha S.</creator><creator>Bondy, Melissa L.</creator><creator>Morris, Debra L.</creator><creator>Legator, Marvin S.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20051218</creationdate><title>Cytogenetic effects in children treated with methylphenidate</title><author>El-Zein, Randa A. ; Abdel-Rahman, Sherif Z. ; Hay, Matthew J. ; Lopez, Mirtha S. ; Bondy, Melissa L. ; Morris, Debra L. ; Legator, Marvin S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-fb40a0b913240009fcaede0a216f58d2cfab6cf7853d88a3e5c0c2cd48ab17b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ADHD</topic><topic>Attention Deficit Disorder with Hyperactivity - drug therapy</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Central Nervous System Stimulants - adverse effects</topic><topic>Central Nervous System Stimulants - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Chromosomal aberrations</topic><topic>Chromosome Aberrations - chemically induced</topic><topic>Chromosomes</topic><topic>Female</topic><topic>Genotoxicity</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Lymphocytes - drug effects</topic><topic>Male</topic><topic>Methylphenidate</topic><topic>Methylphenidate - adverse effects</topic><topic>Methylphenidate - therapeutic use</topic><topic>Micronuclei, Chromosome-Defective - chemically induced</topic><topic>Mutagenicity Tests</topic><topic>Sister Chromatid Exchange</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Zein, Randa A.</creatorcontrib><creatorcontrib>Abdel-Rahman, Sherif Z.</creatorcontrib><creatorcontrib>Hay, Matthew J.</creatorcontrib><creatorcontrib>Lopez, Mirtha S.</creatorcontrib><creatorcontrib>Bondy, Melissa L.</creatorcontrib><creatorcontrib>Morris, Debra L.</creatorcontrib><creatorcontrib>Legator, Marvin S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Zein, Randa A.</au><au>Abdel-Rahman, Sherif Z.</au><au>Hay, Matthew J.</au><au>Lopez, Mirtha S.</au><au>Bondy, Melissa L.</au><au>Morris, Debra L.</au><au>Legator, Marvin S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytogenetic effects in children treated with methylphenidate</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2005-12-18</date><risdate>2005</risdate><volume>230</volume><issue>2</issue><spage>284</spage><epage>291</epage><pages>284-291</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>In recent years there has been a surge in methylphenidate (Ritalin) use for treatment of attention deficit/hyperactivity disorder (ADHD) in children. 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| subjects | ADHD Attention Deficit Disorder with Hyperactivity - drug therapy Attention deficit hyperactivity disorder Central Nervous System Stimulants - adverse effects Central Nervous System Stimulants - therapeutic use Child Child, Preschool Children Chromosomal aberrations Chromosome Aberrations - chemically induced Chromosomes Female Genotoxicity Humans Hyperactivity Lymphocytes - drug effects Male Methylphenidate Methylphenidate - adverse effects Methylphenidate - therapeutic use Micronuclei, Chromosome-Defective - chemically induced Mutagenicity Tests Sister Chromatid Exchange Studies |
| title | Cytogenetic effects in children treated with methylphenidate |
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