Chemopreventive and therapeutic effects of curcumin
Chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. that allows suppression, retardation or inversion of carcinogene...
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| Veröffentlicht in: | Cancer letters 2005-06, Vol.223 (2), p.181-190 |
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| container_end_page | 190 |
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| container_issue | 2 |
| container_start_page | 181 |
| container_title | Cancer letters |
| container_volume | 223 |
| creator | Duvoix, Annelyse Blasius, Romain Delhalle, Sylvie Schnekenburger, Michaël Morceau, Franck Henry, Estelle Dicato, Mario Diederich, Marc |
| description | Chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from
Curcuma longa L. that allows suppression, retardation or inversion of carcinogenesis. Curcumin is also described as an anti-tumoral, anti-oxidant and anti-inflammatory agent capable of inducing apoptosis in numerous cellular systems. In this review, we describe both properties and mode of action of curcumin on carcinogenesis, gene expression mechanisms and drug metabolism. |
| doi_str_mv | 10.1016/j.canlet.2004.09.041 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2005-06, Vol.223 (2), p.181-190 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Breast cancer Cancer Cancer therapies Carcinogens Cell Transformation, Neoplastic - drug effects Chemoprevention Chemopreventive agent Copper Curcumin Curcumin - pharmacology Cytochrome P-450 Enzyme System - metabolism Drug metabolism Enzyme Activation Enzymes Free radicals Humans Kinases Melanoma Neoplasms - prevention & control NF-kappa B - antagonists & inhibitors Proteins Rodents Telomerase Transcription Factors - antagonists & inhibitors Vascular endothelial growth factor |
| title | Chemopreventive and therapeutic effects of curcumin |
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