Inhibition of NMU-induced mammary tumorigenesis by dietary soy
We previously demonstrated that female Sprague–Dawley rats fed AIN-93G diets containing soy protein isolate (SPI +) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 2005-06, Vol.224 (1), p.45-52 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 52 |
|---|---|
| container_issue | 1 |
| container_start_page | 45 |
| container_title | Cancer letters |
| container_volume | 224 |
| creator | Simmen, Rosalia C.M. Eason, Renea R. Till, S. Reneé Chatman, Leon Velarde, Michael C. Geng, Yan Korourian, Sohelia Badger, Thomas M. |
| description | We previously demonstrated that female Sprague–Dawley rats fed AIN-93G diets containing soy protein isolate (SPI
+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these same diets to the direct-acting carcinogen
N-methyl-nitrosourea (NMU). Tumor incidence was reduced and tumor latency was enhanced, in NMU-administered female rats lifetime exposed to SPI
+, relative to the CAS group. Tumor multiplicity did not differ with diet, while tumor grade tended to be more advanced with SPI
+. Normal mammary glands of CAS and SPI
+ tumor-bearing rats had comparable proliferative and apoptotic status. However, mammary expression of HER-2/neu and progesterone receptor (PR) genes was higher for SPI
+ rats. Moreover, tumored SPI
+ rats had lower serum progesterone levels than those fed CAS, while serum estrogen did not differ. Serum from tumored SPI
+ rats had higher apoptotic activity towards mammary epithelial MCF-7 cells, than CAS serum. Thus, dietary soy protects against mammary tumorigenesis induced by a direct-acting carcinogen and alters signaling pathways involving PR and HER-2/neu. |
| doi_str_mv | 10.1016/j.canlet.2004.11.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1505370476</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304383504008596</els_id><sourcerecordid>3241555831</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-5969874e31aa878072e3a981f8c7a850abdf4c4230b4523a31f7d4e7937de0193</originalsourceid><addsrcrecordid>eNp9kE1Lw0AQhhdRbK3-A5GA58SZ7G53cymI-FGoerHnZZNMdEuT1N1E6L83oQVvnuYw7wfvw9g1QoKA87tNUthmS12SAogEMQHITtgUtUpjlWk4ZVPgIGKuuZywixA2ACCFkudsgjJDRIApWyybL5e7zrVN1FbR2-s6dk3ZF1RGta1r6_dR19etd5_UUHAhyvdR6agbH6HdX7Kzym4DXR3vjK2fHj8eXuLV-_Py4X4VF0KKLpbZPNNKEEdrtdKgUuI201jpQlktweZlJQqRcsiFTLnlWKlSkMq4Kgkw4zN2e8jd-fa7p9CZTdv7Zqg0KEFyBULNB5U4qArfhuCpMjvvxg0GwYzQzMYcoJkRmkE0A7TBdnMM7_Oayj_TkdIgWBwENEz8ceRNKBw1AyTnqehM2br_G34Bzrx9lQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1505370476</pqid></control><display><type>article</type><title>Inhibition of NMU-induced mammary tumorigenesis by dietary soy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Simmen, Rosalia C.M. ; Eason, Renea R. ; Till, S. Reneé ; Chatman, Leon ; Velarde, Michael C. ; Geng, Yan ; Korourian, Sohelia ; Badger, Thomas M.</creator><creatorcontrib>Simmen, Rosalia C.M. ; Eason, Renea R. ; Till, S. Reneé ; Chatman, Leon ; Velarde, Michael C. ; Geng, Yan ; Korourian, Sohelia ; Badger, Thomas M.</creatorcontrib><description>We previously demonstrated that female Sprague–Dawley rats fed AIN-93G diets containing soy protein isolate (SPI
+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these same diets to the direct-acting carcinogen
N-methyl-nitrosourea (NMU). Tumor incidence was reduced and tumor latency was enhanced, in NMU-administered female rats lifetime exposed to SPI
+, relative to the CAS group. Tumor multiplicity did not differ with diet, while tumor grade tended to be more advanced with SPI
+. Normal mammary glands of CAS and SPI
+ tumor-bearing rats had comparable proliferative and apoptotic status. However, mammary expression of HER-2/neu and progesterone receptor (PR) genes was higher for SPI
+ rats. Moreover, tumored SPI
+ rats had lower serum progesterone levels than those fed CAS, while serum estrogen did not differ. Serum from tumored SPI
+ rats had higher apoptotic activity towards mammary epithelial MCF-7 cells, than CAS serum. Thus, dietary soy protects against mammary tumorigenesis induced by a direct-acting carcinogen and alters signaling pathways involving PR and HER-2/neu.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2004.11.009</identifier><identifier>PMID: 15911100</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Alkylating Agents - toxicity ; Animals ; Apoptosis ; Breast cancer ; Breast Neoplasms - prevention & control ; Carcinogens ; Cell culture ; Cell Proliferation ; Chemoprevention ; Diet ; Disease Models, Animal ; DNA repair ; Female ; Gene expression ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Mammary carcinoma ; Mammary Neoplasms, Experimental - chemically induced ; Mammary Neoplasms, Experimental - prevention & control ; Methylnitrosourea - toxicity ; NMU ; Progesterone ; Proteins ; Rats ; Receptor, ErbB-2 - biosynthesis ; Receptors, Progesterone - biosynthesis ; Rodents ; Soy proteins ; Soybean Proteins - pharmacology ; Tumorigenesis ; Tumors</subject><ispartof>Cancer letters, 2005-06, Vol.224 (1), p.45-52</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Jun 16, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-5969874e31aa878072e3a981f8c7a850abdf4c4230b4523a31f7d4e7937de0193</citedby><cites>FETCH-LOGICAL-c454t-5969874e31aa878072e3a981f8c7a850abdf4c4230b4523a31f7d4e7937de0193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383504008596$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15911100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simmen, Rosalia C.M.</creatorcontrib><creatorcontrib>Eason, Renea R.</creatorcontrib><creatorcontrib>Till, S. Reneé</creatorcontrib><creatorcontrib>Chatman, Leon</creatorcontrib><creatorcontrib>Velarde, Michael C.</creatorcontrib><creatorcontrib>Geng, Yan</creatorcontrib><creatorcontrib>Korourian, Sohelia</creatorcontrib><creatorcontrib>Badger, Thomas M.</creatorcontrib><title>Inhibition of NMU-induced mammary tumorigenesis by dietary soy</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>We previously demonstrated that female Sprague–Dawley rats fed AIN-93G diets containing soy protein isolate (SPI
+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these same diets to the direct-acting carcinogen
N-methyl-nitrosourea (NMU). Tumor incidence was reduced and tumor latency was enhanced, in NMU-administered female rats lifetime exposed to SPI
+, relative to the CAS group. Tumor multiplicity did not differ with diet, while tumor grade tended to be more advanced with SPI
+. Normal mammary glands of CAS and SPI
+ tumor-bearing rats had comparable proliferative and apoptotic status. However, mammary expression of HER-2/neu and progesterone receptor (PR) genes was higher for SPI
+ rats. Moreover, tumored SPI
+ rats had lower serum progesterone levels than those fed CAS, while serum estrogen did not differ. Serum from tumored SPI
+ rats had higher apoptotic activity towards mammary epithelial MCF-7 cells, than CAS serum. Thus, dietary soy protects against mammary tumorigenesis induced by a direct-acting carcinogen and alters signaling pathways involving PR and HER-2/neu.</description><subject>Alkylating Agents - toxicity</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - prevention & control</subject><subject>Carcinogens</subject><subject>Cell culture</subject><subject>Cell Proliferation</subject><subject>Chemoprevention</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>DNA repair</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Nick-End Labeling</subject><subject>Mammary carcinoma</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Mammary Neoplasms, Experimental - prevention & control</subject><subject>Methylnitrosourea - toxicity</subject><subject>NMU</subject><subject>Progesterone</subject><subject>Proteins</subject><subject>Rats</subject><subject>Receptor, ErbB-2 - biosynthesis</subject><subject>Receptors, Progesterone - biosynthesis</subject><subject>Rodents</subject><subject>Soy proteins</subject><subject>Soybean Proteins - pharmacology</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3-A5GA58SZ7G53cymI-FGoerHnZZNMdEuT1N1E6L83oQVvnuYw7wfvw9g1QoKA87tNUthmS12SAogEMQHITtgUtUpjlWk4ZVPgIGKuuZywixA2ACCFkudsgjJDRIApWyybL5e7zrVN1FbR2-s6dk3ZF1RGta1r6_dR19etd5_UUHAhyvdR6agbH6HdX7Kzym4DXR3vjK2fHj8eXuLV-_Py4X4VF0KKLpbZPNNKEEdrtdKgUuI201jpQlktweZlJQqRcsiFTLnlWKlSkMq4Kgkw4zN2e8jd-fa7p9CZTdv7Zqg0KEFyBULNB5U4qArfhuCpMjvvxg0GwYzQzMYcoJkRmkE0A7TBdnMM7_Oayj_TkdIgWBwENEz8ceRNKBw1AyTnqehM2br_G34Bzrx9lQ</recordid><startdate>20050616</startdate><enddate>20050616</enddate><creator>Simmen, Rosalia C.M.</creator><creator>Eason, Renea R.</creator><creator>Till, S. Reneé</creator><creator>Chatman, Leon</creator><creator>Velarde, Michael C.</creator><creator>Geng, Yan</creator><creator>Korourian, Sohelia</creator><creator>Badger, Thomas M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20050616</creationdate><title>Inhibition of NMU-induced mammary tumorigenesis by dietary soy</title><author>Simmen, Rosalia C.M. ; Eason, Renea R. ; Till, S. Reneé ; Chatman, Leon ; Velarde, Michael C. ; Geng, Yan ; Korourian, Sohelia ; Badger, Thomas M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-5969874e31aa878072e3a981f8c7a850abdf4c4230b4523a31f7d4e7937de0193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Alkylating Agents - toxicity</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - prevention & control</topic><topic>Carcinogens</topic><topic>Cell culture</topic><topic>Cell Proliferation</topic><topic>Chemoprevention</topic><topic>Diet</topic><topic>Disease Models, Animal</topic><topic>DNA repair</topic><topic>Female</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Nick-End Labeling</topic><topic>Mammary carcinoma</topic><topic>Mammary Neoplasms, Experimental - chemically induced</topic><topic>Mammary Neoplasms, Experimental - prevention & control</topic><topic>Methylnitrosourea - toxicity</topic><topic>NMU</topic><topic>Progesterone</topic><topic>Proteins</topic><topic>Rats</topic><topic>Receptor, ErbB-2 - biosynthesis</topic><topic>Receptors, Progesterone - biosynthesis</topic><topic>Rodents</topic><topic>Soy proteins</topic><topic>Soybean Proteins - pharmacology</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simmen, Rosalia C.M.</creatorcontrib><creatorcontrib>Eason, Renea R.</creatorcontrib><creatorcontrib>Till, S. Reneé</creatorcontrib><creatorcontrib>Chatman, Leon</creatorcontrib><creatorcontrib>Velarde, Michael C.</creatorcontrib><creatorcontrib>Geng, Yan</creatorcontrib><creatorcontrib>Korourian, Sohelia</creatorcontrib><creatorcontrib>Badger, Thomas M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simmen, Rosalia C.M.</au><au>Eason, Renea R.</au><au>Till, S. Reneé</au><au>Chatman, Leon</au><au>Velarde, Michael C.</au><au>Geng, Yan</au><au>Korourian, Sohelia</au><au>Badger, Thomas M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of NMU-induced mammary tumorigenesis by dietary soy</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2005-06-16</date><risdate>2005</risdate><volume>224</volume><issue>1</issue><spage>45</spage><epage>52</epage><pages>45-52</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>We previously demonstrated that female Sprague–Dawley rats fed AIN-93G diets containing soy protein isolate (SPI
+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these same diets to the direct-acting carcinogen
N-methyl-nitrosourea (NMU). Tumor incidence was reduced and tumor latency was enhanced, in NMU-administered female rats lifetime exposed to SPI
+, relative to the CAS group. Tumor multiplicity did not differ with diet, while tumor grade tended to be more advanced with SPI
+. Normal mammary glands of CAS and SPI
+ tumor-bearing rats had comparable proliferative and apoptotic status. However, mammary expression of HER-2/neu and progesterone receptor (PR) genes was higher for SPI
+ rats. Moreover, tumored SPI
+ rats had lower serum progesterone levels than those fed CAS, while serum estrogen did not differ. Serum from tumored SPI
+ rats had higher apoptotic activity towards mammary epithelial MCF-7 cells, than CAS serum. Thus, dietary soy protects against mammary tumorigenesis induced by a direct-acting carcinogen and alters signaling pathways involving PR and HER-2/neu.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15911100</pmid><doi>10.1016/j.canlet.2004.11.009</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2005-06, Vol.224 (1), p.45-52 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_journals_1505370476 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alkylating Agents - toxicity Animals Apoptosis Breast cancer Breast Neoplasms - prevention & control Carcinogens Cell culture Cell Proliferation Chemoprevention Diet Disease Models, Animal DNA repair Female Gene expression Humans Immunohistochemistry In Situ Nick-End Labeling Mammary carcinoma Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - prevention & control Methylnitrosourea - toxicity NMU Progesterone Proteins Rats Receptor, ErbB-2 - biosynthesis Receptors, Progesterone - biosynthesis Rodents Soy proteins Soybean Proteins - pharmacology Tumorigenesis Tumors |
| title | Inhibition of NMU-induced mammary tumorigenesis by dietary soy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T03%3A31%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibition%20of%20NMU-induced%20mammary%20tumorigenesis%20by%20dietary%20soy&rft.jtitle=Cancer%20letters&rft.au=Simmen,%20Rosalia%20C.M.&rft.date=2005-06-16&rft.volume=224&rft.issue=1&rft.spage=45&rft.epage=52&rft.pages=45-52&rft.issn=0304-3835&rft.eissn=1872-7980&rft_id=info:doi/10.1016/j.canlet.2004.11.009&rft_dat=%3Cproquest_cross%3E3241555831%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1505370476&rft_id=info:pmid/15911100&rft_els_id=S0304383504008596&rfr_iscdi=true |