Overexpression of DcR1 and survivin in genetically modified cells with pleiotropic drug resistance

A previously identified set of short cDNA fragments (genetic suppressor elements, GSEs) expressed in human HT1080 cells protects them against several chemotherapeutic drugs. We show here that DNA damaging agent cytosine arabinoside can induce apoptosis in GSE-containing drug-resistant derivatives (M...

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Veröffentlicht in:	Cancer letters 2004-08, Vol.211 (2), p.189-197
Hauptverfasser:	Davidovich, Irina A, Levenson, Anait S, Levenson (Chernokhvostov), Victor V
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Antimetabolites, Antineoplastic - pharmacology Apoptosis Cancer Cancer therapies Cycloheximide Cycloheximide - pharmacology Cytarabine - pharmacology Cytotoxicity Deoxyribonucleic acid DNA DNA Damage Drug dosages Drug resistance Drug Resistance, Neoplasm Experiments Fibrosarcoma - pathology Genes, Suppressor GPI-Linked Proteins Humans Inhibitor of Apoptosis Proteins Ligands Microtubule-Associated Proteins - biosynthesis Neoplasm Proteins Protein synthesis Proteins Receptors, Tumor Necrosis Factor - biosynthesis Receptors, Tumor Necrosis Factor, Member 10c Rodents Signal transduction Substance abuse treatment Tumor Cells, Cultured Tumor Necrosis Factor Decoy Receptors Tumors
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