Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Ch...
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| Veröffentlicht in: | Cancer letters 2004-06, Vol.209 (1), p.1-6 |
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| creator | Nikiforova, Marina N Ciampi, Raffaele Salvatore, Giuliana Santoro, Massimo Gandhi, Manoj Knauf, Jeffrey A Thomas, Gerry A Jeremiah, Stephen Bogdanova, Tatyana I Tronko, Mykola D Fagin, James A Nikiforov, Yuri E |
| description | Point mutations of the
BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of
BRAF point mutations and
RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of
BRAF point mutations and high prevalence (58%) of
RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring
BRAF mutations and 20%
RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors. |
| doi_str_mv | 10.1016/j.canlet.2003.12.004 |
| format | Article |
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BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of
BRAF point mutations and
RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of
BRAF point mutations and high prevalence (58%) of
RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring
BRAF mutations and 20%
RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2003.12.004</identifier><identifier>PMID: 15145515</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; BRAF mutation ; Carcinoma, Papillary - genetics ; Carcinoma, Papillary - metabolism ; Child ; Humans ; Kinases ; Medical research ; Mutation ; Neoplasms, Radiation-Induced - genetics ; Neoplasms, Radiation-Induced - metabolism ; Point Mutation ; Polymerase Chain Reaction ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins B-raf ; Proto-Oncogene Proteins c-raf - biosynthesis ; Proto-Oncogene Proteins c-raf - genetics ; Proto-Oncogene Proteins c-ret ; Radiation exposure ; Receptor Protein-Tyrosine Kinases - genetics ; RET/PTC Rearrangement ; Temperature ; Thyroid cancer ; Thyroid Neoplasms - etiology ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - metabolism</subject><ispartof>Cancer letters, 2004-06, Vol.209 (1), p.1-6</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Jun 1, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-ddadd4081c2770de5fa315f7d61ac2695f2c096eb8e8abfb7969380e88414a4f3</citedby><cites>FETCH-LOGICAL-c452t-ddadd4081c2770de5fa315f7d61ac2695f2c096eb8e8abfb7969380e88414a4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2003.12.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15145515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nikiforova, Marina N</creatorcontrib><creatorcontrib>Ciampi, Raffaele</creatorcontrib><creatorcontrib>Salvatore, Giuliana</creatorcontrib><creatorcontrib>Santoro, Massimo</creatorcontrib><creatorcontrib>Gandhi, Manoj</creatorcontrib><creatorcontrib>Knauf, Jeffrey A</creatorcontrib><creatorcontrib>Thomas, Gerry A</creatorcontrib><creatorcontrib>Jeremiah, Stephen</creatorcontrib><creatorcontrib>Bogdanova, Tatyana I</creatorcontrib><creatorcontrib>Tronko, Mykola D</creatorcontrib><creatorcontrib>Fagin, James A</creatorcontrib><creatorcontrib>Nikiforov, Yuri E</creatorcontrib><title>Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Point mutations of the
BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of
BRAF point mutations and
RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of
BRAF point mutations and high prevalence (58%) of
RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring
BRAF mutations and 20%
RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.</description><subject>Adolescent</subject><subject>Adult</subject><subject>BRAF mutation</subject><subject>Carcinoma, Papillary - genetics</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Child</subject><subject>Humans</subject><subject>Kinases</subject><subject>Medical research</subject><subject>Mutation</subject><subject>Neoplasms, Radiation-Induced - genetics</subject><subject>Neoplasms, Radiation-Induced - metabolism</subject><subject>Point Mutation</subject><subject>Polymerase Chain Reaction</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins B-raf</subject><subject>Proto-Oncogene Proteins c-raf - biosynthesis</subject><subject>Proto-Oncogene Proteins c-raf - genetics</subject><subject>Proto-Oncogene Proteins c-ret</subject><subject>Radiation exposure</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>RET/PTC Rearrangement</subject><subject>Temperature</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - etiology</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - metabolism</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOo6-gUjAdetJm7TpRlBxVBgQRNchk6SYoW1qkiq-vZkLuHN1OPD95_IhdEEgJ0Cq63Wu5NCZmBcAZU6KHIAeoBnhdZHVDYdDNIMSaFbykp2g0xDWAMBozY7RCWGEMkbYDH0u3TcevfmSnRmUwa7Fd6-3C9xPUUbrhoDtgL3UdttldtCTMhrHjx_vbKpT7_yWUW6IXoaIo8NhdJuIwqMcbddJ_4OV9MoOrpfhDB21sgvmfF_n6H3x8Hb_lC1fHp_vb5eZoqyImdZSawqcqKKuQRvWypKwttYVkaqoGtYWCprKrLjhctWu6qZqSg6Gc0qopG05R1e7uaN3n5MJUazd5Ie0UhAGrKzqpCdRdEcp70LwphWjt326WBAQG89iLXaexcazIIVInlPscj98WvVG_4X2YhNwswNMevHLGi-CshvD2nqjotDO_r_hF-YNkho</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Nikiforova, Marina N</creator><creator>Ciampi, Raffaele</creator><creator>Salvatore, Giuliana</creator><creator>Santoro, Massimo</creator><creator>Gandhi, Manoj</creator><creator>Knauf, Jeffrey A</creator><creator>Thomas, Gerry A</creator><creator>Jeremiah, Stephen</creator><creator>Bogdanova, Tatyana I</creator><creator>Tronko, Mykola D</creator><creator>Fagin, James A</creator><creator>Nikiforov, Yuri E</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>200406</creationdate><title>Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas</title><author>Nikiforova, Marina N ; Ciampi, Raffaele ; Salvatore, Giuliana ; Santoro, Massimo ; Gandhi, Manoj ; Knauf, Jeffrey A ; Thomas, Gerry A ; Jeremiah, Stephen ; Bogdanova, Tatyana I ; Tronko, Mykola D ; Fagin, James A ; Nikiforov, Yuri E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-ddadd4081c2770de5fa315f7d61ac2695f2c096eb8e8abfb7969380e88414a4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>BRAF mutation</topic><topic>Carcinoma, Papillary - genetics</topic><topic>Carcinoma, Papillary - metabolism</topic><topic>Child</topic><topic>Humans</topic><topic>Kinases</topic><topic>Medical research</topic><topic>Mutation</topic><topic>Neoplasms, Radiation-Induced - genetics</topic><topic>Neoplasms, Radiation-Induced - metabolism</topic><topic>Point Mutation</topic><topic>Polymerase Chain Reaction</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins B-raf</topic><topic>Proto-Oncogene Proteins c-raf - biosynthesis</topic><topic>Proto-Oncogene Proteins c-raf - genetics</topic><topic>Proto-Oncogene Proteins c-ret</topic><topic>Radiation exposure</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>RET/PTC Rearrangement</topic><topic>Temperature</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - etiology</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikiforova, Marina N</creatorcontrib><creatorcontrib>Ciampi, Raffaele</creatorcontrib><creatorcontrib>Salvatore, Giuliana</creatorcontrib><creatorcontrib>Santoro, Massimo</creatorcontrib><creatorcontrib>Gandhi, Manoj</creatorcontrib><creatorcontrib>Knauf, Jeffrey A</creatorcontrib><creatorcontrib>Thomas, Gerry A</creatorcontrib><creatorcontrib>Jeremiah, Stephen</creatorcontrib><creatorcontrib>Bogdanova, Tatyana I</creatorcontrib><creatorcontrib>Tronko, Mykola D</creatorcontrib><creatorcontrib>Fagin, James A</creatorcontrib><creatorcontrib>Nikiforov, Yuri E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikiforova, Marina N</au><au>Ciampi, Raffaele</au><au>Salvatore, Giuliana</au><au>Santoro, Massimo</au><au>Gandhi, Manoj</au><au>Knauf, Jeffrey A</au><au>Thomas, Gerry A</au><au>Jeremiah, Stephen</au><au>Bogdanova, Tatyana I</au><au>Tronko, Mykola D</au><au>Fagin, James A</au><au>Nikiforov, Yuri E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2004-06</date><risdate>2004</risdate><volume>209</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Point mutations of the
BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of
BRAF point mutations and
RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of
BRAF point mutations and high prevalence (58%) of
RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring
BRAF mutations and 20%
RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15145515</pmid><doi>10.1016/j.canlet.2003.12.004</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult BRAF mutation Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Child Humans Kinases Medical research Mutation Neoplasms, Radiation-Induced - genetics Neoplasms, Radiation-Induced - metabolism Point Mutation Polymerase Chain Reaction Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins c-raf - biosynthesis Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins c-ret Radiation exposure Receptor Protein-Tyrosine Kinases - genetics RET/PTC Rearrangement Temperature Thyroid cancer Thyroid Neoplasms - etiology Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism |
| title | Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas |
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