G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus ( Vitex rotundifolia Linne fil.)

Flavonoids are distributed in many plants. We studied the antitumor effects of flavonoids isolated from Viticis Fructus, casticin, artemetin, quercetagetin and 5,3′-dihydroxy-6,7,4′ -trimethoxyflavanone. Casticin inhibited the growth of KB cells markedly (IC 50=0.23 μM), compared with the other flav...

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Veröffentlicht in:	Cancer letters 2004-05, Vol.208 (1), p.59-64
Hauptverfasser:	Kobayakawa, Junko, Sato-Nishimori, Fumiko, Moriyasu, Masataka, Matsukawa, Yoshizumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors Amino acids Animals Antimitosis Arrests Cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Casticin Cell culture Cell cycle Cell Division - drug effects Cells, Cultured Chromones - pharmacology Drug dosages Flavonoid Flavonoids - isolation & purification Flavonoids - pharmacology G2 Phase - drug effects G2-M arrest Humans Immunization KB Cells Mice Mitosis - drug effects Normal cells Polymerization Spindle Apparatus - drug effects Swiss 3T3 Cells Vitex - chemistry
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