Lack of prognostic significance of survivin, survivin-[Delta]Ex3, survivin-2B, galectin-3, bag-1, bax-[alpha] and MRP-1 mRNAs in breast cancer
The expression of transcripts for anti-apoptotic (survivin, survivin-ΔEx3, survivin-2B, galectin-3, bag-1 and bcl-2) and pro-apoptotic (bax-[alpha]) genes, and for multiple drug resistance related protein-1 (MRP-1) gene were investigated, using RT-PCR, in 106 breast tumour biopsies. Normal breast ti...
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| Veröffentlicht in: | Cancer letters 2003-11, Vol.201 (2), p.225 |
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| creator | O'Driscoll, Lorraine Linehan, Rasha M Kennedy, Susan Cronin, Deirdre Purcell, Rachel Glynn, Sharon W McDermott, Enda D Hill, Arnold J O'Higgins, Niall Parkinson, Michael Clynes, Martin |
| description | The expression of transcripts for anti-apoptotic (survivin, survivin-ΔEx3, survivin-2B, galectin-3, bag-1 and bcl-2) and pro-apoptotic (bax-[alpha]) genes, and for multiple drug resistance related protein-1 (MRP-1) gene were investigated, using RT-PCR, in 106 breast tumour biopsies. Normal breast tissue was also analysed for comparative purposes. Overall, survivin, survivin-ΔEx3, survivin-2B, bcl-2, bag-1, galectin-3, bax-[alpha] and MRP-1 mRNAs were detected in 68, 54.7, 9.4, 78.4, 80.9, 98.9, 97.8 and 72.8%, respectively, of tumour specimens. Uniquely among the mRNAs analysed, the expression of bcl-2 correlated significantly with disease outcome, with bcl-2 expression indicative of favourable outcome in terms of both relapse-free survival and overall survival. This suggests that bcl-2 mRNA expression may be a key prognostic marker for breast cancer and that routine analysis of expression of this transcript should be considered. The results from this study suggest, however, that the expression of survivin, survivin-ΔEx3, survivin-2B, bag-1, galectin-3, bax-[alpha] and MRP-1 mRNAs cannot be considered as prognostic indicators of disease outcome for patients with breast cancer. |
| doi_str_mv | 10.1016/S0304-3835(03)00518-4 |
| format | Article |
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Normal breast tissue was also analysed for comparative purposes. Overall, survivin, survivin-ΔEx3, survivin-2B, bcl-2, bag-1, galectin-3, bax-[alpha] and MRP-1 mRNAs were detected in 68, 54.7, 9.4, 78.4, 80.9, 98.9, 97.8 and 72.8%, respectively, of tumour specimens. Uniquely among the mRNAs analysed, the expression of bcl-2 correlated significantly with disease outcome, with bcl-2 expression indicative of favourable outcome in terms of both relapse-free survival and overall survival. This suggests that bcl-2 mRNA expression may be a key prognostic marker for breast cancer and that routine analysis of expression of this transcript should be considered. The results from this study suggest, however, that the expression of survivin, survivin-ΔEx3, survivin-2B, bag-1, galectin-3, bax-[alpha] and MRP-1 mRNAs cannot be considered as prognostic indicators of disease outcome for patients with breast cancer.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(03)00518-4</identifier><language>eng</language><publisher>Clare: Elsevier Limited</publisher><subject>Breast cancer ; Genes ; Histology ; Medical prognosis ; Multivariate analysis ; Patients ; Protein expression ; Proteins ; Studies ; Tumors</subject><ispartof>Cancer letters, 2003-11, Vol.201 (2), p.225</ispartof><rights>Copyright Elsevier Limited Nov 25, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>O'Driscoll, Lorraine</creatorcontrib><creatorcontrib>Linehan, Rasha</creatorcontrib><creatorcontrib>M Kennedy, Susan</creatorcontrib><creatorcontrib>Cronin, Deirdre</creatorcontrib><creatorcontrib>Purcell, Rachel</creatorcontrib><creatorcontrib>Glynn, Sharon</creatorcontrib><creatorcontrib>W McDermott, Enda</creatorcontrib><creatorcontrib>D Hill, Arnold</creatorcontrib><creatorcontrib>J O'Higgins, Niall</creatorcontrib><creatorcontrib>Parkinson, Michael</creatorcontrib><creatorcontrib>Clynes, Martin</creatorcontrib><title>Lack of prognostic significance of survivin, survivin-[Delta]Ex3, survivin-2B, galectin-3, bag-1, bax-[alpha] and MRP-1 mRNAs in breast cancer</title><title>Cancer letters</title><description>The expression of transcripts for anti-apoptotic (survivin, survivin-ΔEx3, survivin-2B, galectin-3, bag-1 and bcl-2) and pro-apoptotic (bax-[alpha]) genes, and for multiple drug resistance related protein-1 (MRP-1) gene were investigated, using RT-PCR, in 106 breast tumour biopsies. Normal breast tissue was also analysed for comparative purposes. Overall, survivin, survivin-ΔEx3, survivin-2B, bcl-2, bag-1, galectin-3, bax-[alpha] and MRP-1 mRNAs were detected in 68, 54.7, 9.4, 78.4, 80.9, 98.9, 97.8 and 72.8%, respectively, of tumour specimens. Uniquely among the mRNAs analysed, the expression of bcl-2 correlated significantly with disease outcome, with bcl-2 expression indicative of favourable outcome in terms of both relapse-free survival and overall survival. This suggests that bcl-2 mRNA expression may be a key prognostic marker for breast cancer and that routine analysis of expression of this transcript should be considered. The results from this study suggest, however, that the expression of survivin, survivin-ΔEx3, survivin-2B, bag-1, galectin-3, bax-[alpha] and MRP-1 mRNAs cannot be considered as prognostic indicators of disease outcome for patients with breast cancer.</description><subject>Breast cancer</subject><subject>Genes</subject><subject>Histology</subject><subject>Medical prognosis</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Studies</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNjk1LAzEQhoMouH78BGHAi0Kjk81mdz36UfGgItVbKWUas2vqmq3Jbumv8DebihSPnt6Z93lghrEjgWcCRX7-jBIzLkupTlCeIipR8myLJaIsUl5clLjNko2yy_ZCmGO0skIl7Oue9Du0FSx8W7s2dFZDsLWzldXktFmj0PulXVo32Ex8fGOajibDlfxTplcDqKkxuotLBDOquVjHio-pWbzRBMi9wsPoiQv4GD1eBrAOZt5Q6ODnmj9gOxU1wRz-5j47vh2-XN_x-N5nb0I3nbe9dxFNhUIlc5Wnqfyf9Q17blnq</recordid><startdate>20031125</startdate><enddate>20031125</enddate><creator>O'Driscoll, Lorraine</creator><creator>Linehan, Rasha</creator><creator>M Kennedy, Susan</creator><creator>Cronin, Deirdre</creator><creator>Purcell, Rachel</creator><creator>Glynn, Sharon</creator><creator>W McDermott, Enda</creator><creator>D Hill, Arnold</creator><creator>J O'Higgins, Niall</creator><creator>Parkinson, Michael</creator><creator>Clynes, Martin</creator><general>Elsevier Limited</general><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20031125</creationdate><title>Lack of prognostic significance of survivin, survivin-[Delta]Ex3, survivin-2B, galectin-3, bag-1, bax-[alpha] and MRP-1 mRNAs in breast cancer</title><author>O'Driscoll, Lorraine ; Linehan, Rasha ; M Kennedy, Susan ; Cronin, Deirdre ; Purcell, Rachel ; Glynn, Sharon ; W McDermott, Enda ; D Hill, Arnold ; J O'Higgins, Niall ; Parkinson, Michael ; Clynes, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_15053656223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Breast cancer</topic><topic>Genes</topic><topic>Histology</topic><topic>Medical prognosis</topic><topic>Multivariate analysis</topic><topic>Patients</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Driscoll, Lorraine</creatorcontrib><creatorcontrib>Linehan, Rasha</creatorcontrib><creatorcontrib>M Kennedy, Susan</creatorcontrib><creatorcontrib>Cronin, Deirdre</creatorcontrib><creatorcontrib>Purcell, Rachel</creatorcontrib><creatorcontrib>Glynn, Sharon</creatorcontrib><creatorcontrib>W McDermott, Enda</creatorcontrib><creatorcontrib>D Hill, Arnold</creatorcontrib><creatorcontrib>J O'Higgins, Niall</creatorcontrib><creatorcontrib>Parkinson, Michael</creatorcontrib><creatorcontrib>Clynes, Martin</creatorcontrib><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Driscoll, Lorraine</au><au>Linehan, Rasha</au><au>M Kennedy, Susan</au><au>Cronin, Deirdre</au><au>Purcell, Rachel</au><au>Glynn, Sharon</au><au>W McDermott, Enda</au><au>D Hill, Arnold</au><au>J O'Higgins, Niall</au><au>Parkinson, Michael</au><au>Clynes, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of prognostic significance of survivin, survivin-[Delta]Ex3, survivin-2B, galectin-3, bag-1, bax-[alpha] and MRP-1 mRNAs in breast cancer</atitle><jtitle>Cancer letters</jtitle><date>2003-11-25</date><risdate>2003</risdate><volume>201</volume><issue>2</issue><spage>225</spage><pages>225-</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>The expression of transcripts for anti-apoptotic (survivin, survivin-ΔEx3, survivin-2B, galectin-3, bag-1 and bcl-2) and pro-apoptotic (bax-[alpha]) genes, and for multiple drug resistance related protein-1 (MRP-1) gene were investigated, using RT-PCR, in 106 breast tumour biopsies. Normal breast tissue was also analysed for comparative purposes. Overall, survivin, survivin-ΔEx3, survivin-2B, bcl-2, bag-1, galectin-3, bax-[alpha] and MRP-1 mRNAs were detected in 68, 54.7, 9.4, 78.4, 80.9, 98.9, 97.8 and 72.8%, respectively, of tumour specimens. Uniquely among the mRNAs analysed, the expression of bcl-2 correlated significantly with disease outcome, with bcl-2 expression indicative of favourable outcome in terms of both relapse-free survival and overall survival. This suggests that bcl-2 mRNA expression may be a key prognostic marker for breast cancer and that routine analysis of expression of this transcript should be considered. The results from this study suggest, however, that the expression of survivin, survivin-ΔEx3, survivin-2B, bag-1, galectin-3, bax-[alpha] and MRP-1 mRNAs cannot be considered as prognostic indicators of disease outcome for patients with breast cancer.</abstract><cop>Clare</cop><pub>Elsevier Limited</pub><doi>10.1016/S0304-3835(03)00518-4</doi></addata></record> |
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| subjects | Breast cancer Genes Histology Medical prognosis Multivariate analysis Patients Protein expression Proteins Studies Tumors |
| title | Lack of prognostic significance of survivin, survivin-[Delta]Ex3, survivin-2B, galectin-3, bag-1, bax-[alpha] and MRP-1 mRNAs in breast cancer |
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