Lack of modification of 2-amino-3,8-dimethylimidazo[4,5- f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole – a CYP1A2 inducer

Fenbendazole (FBZ) is an anthelmintic drug known to be a potent CYP1A2 inducer. Combined effects of FBZ on 2-amino-3,8-dimethylimidazo[4,5- f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats were investigated using a medium-term liver bioassay system. No modifying influence was found in term...

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Veröffentlicht in:	Cancer letters 2002-11, Vol.185 (1), p.39-45
Hauptverfasser:	Suzuki, Shugo, Takahashi, Satoru, Asamoto, Makoto, Inaguma, Shingo, Ogiso, Tadashi, Hirose, Masao, Shirai, Tomoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-3,8-dimethylimidazo[4,5- f]quinoxaline Animals Antinematodal Agents - pharmacology Arylamine N-Acetyltransferase - genetics Arylamine N-Acetyltransferase - metabolism Bioassays Biological and medical sciences Blotting, Western Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - enzymology Chemical agents CYP1A2 Cytochrome P-450 CYP1A2 - metabolism DNA Primers - chemistry Drug Combinations Drug Synergism Enzyme Induction Fenbendazole Fenbendazole - pharmacology Food Glutathione Transferase - metabolism Hepatocarcinogenesis Immunoenzyme Techniques Liver - drug effects Liver - enzymology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - enzymology Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology Quinoxalines - toxicity Rat Rats Rats, Inbred F344 Reverse Transcriptase Polymerase Chain Reaction Rodents Tumors
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