High content screening applied to large-scale cell biology
High Content Screening (HCS) has been useful as an early drug-discovery platform for defining the functions of genes, proteins and other biomolecules in normal and abnormal cellular functions. The same concept of integrating and automating cell-sample preparation, fluorescent labeling, image acquisi...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2004, Vol.22 (1), p.15-22 |
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| container_title | Trends in biotechnology (Regular ed.) |
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| creator | Abraham, Vivek C Taylor, D.Lansing Haskins, Jeffrey R |
| description | High Content Screening (HCS) has been useful as an early drug-discovery platform for defining the functions of genes, proteins and other biomolecules in normal and abnormal cellular functions. The same concept of integrating and automating cell-sample preparation, fluorescent labeling, image acquisition, image processing, image analysis, information management and knowledge mining is now beginning to have an impact in basic biomedical research. These integrated tools allow an increase in the scale of cell biological investigations to large-scale cell biology and their value is demonstrated by the rapid performance of a kinetic, multiparameter cytotoxicity assay enabling generation of 10
8 individual physiological cellular measurements in less than one day. |
| doi_str_mv | 10.1016/j.tibtech.2003.10.012 |
| format | Article |
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8 individual physiological cellular measurements in less than one day.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>14690618</pmid><doi>10.1016/j.tibtech.2003.10.012</doi><tpages>8</tpages></addata></record> |
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| ispartof | Trends in biotechnology (Regular ed.), 2004, Vol.22 (1), p.15-22 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Automation Biological and medical sciences Biology Biopolymers - metabolism Biotechnology Cell Culture Techniques - methods Cell Culture Techniques - trends Cell Physiological Phenomena Cytotoxicity Database Management Systems Diverse techniques Experiments Fundamental and applied biological sciences. Psychology Gene Expression Profiling - methods Gene Expression Profiling - trends Information Storage and Retrieval - methods Information Storage and Retrieval - trends Microscopy Molecular and cellular biology Protein Interaction Mapping - methods Protein Interaction Mapping - trends Robotics - methods Robotics - trends Sample preparation Software Specimen Handling - methods Specimen Handling - trends Systems Integration Toxicity Tests - methods Toxicity Tests - trends User-Computer Interface |
| title | High content screening applied to large-scale cell biology |
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