A Mouse Model of Picornavirus-induced Airway Infection and Inflammation

A Mouse Model of Picornavirus-induced Airway Infection and Inflammation

Mice inoculated with attenuated mengovirus, compared with those inoculated with vehicle or UV-inactivated virus, shed infectious virus for 5 days, had peribronchiolar, perivascular, and alveolar cellular infiltrates, had significantly elevated (p < 0.05) levels of BAL neutrophils, neutrophil chem...

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Veröffentlicht in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB151-AB151
Hauptverfasser: Rosenthal, L.A, Szakaly, R.J, Amineva, S.P, Hill, M.R, Palmenberg, A.C, Gern, J.E, Sorkness, R.L
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Allergy and Immunology
Asthma
Medical research
Rodents
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container_end_page AB151
container_issue 2
container_start_page AB151
container_title Journal of allergy and clinical immunology
container_volume 125
creator Rosenthal, L.A
Szakaly, R.J
Amineva, S.P
Hill, M.R
Palmenberg, A.C
Gern, J.E
Sorkness, R.L
description Mice inoculated with attenuated mengovirus, compared with those inoculated with vehicle or UV-inactivated virus, shed infectious virus for 5 days, had peribronchiolar, perivascular, and alveolar cellular infiltrates, had significantly elevated (p < 0.05) levels of BAL neutrophils, neutrophil chemoattractant CXCR2 ligands (CXCL1, CXCL2, CXCL5), other chemokines/cytokines upregulated during rhinovirus infections (CXCL10, CCL2, and interferon-α, -β, and -λ), and exhibited significant increases (p < 0.05) in BAL fluid myeloperoxidase levels and wet-dry lung weight ratios, indicating neutrophil activation and airway injury, respectively.
doi_str_mv 10.1016/j.jaci.2009.12.594
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subjects Allergy and Immunology
Asthma
Medical research
Rodents
title A Mouse Model of Picornavirus-induced Airway Infection and Inflammation
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