VLA-4 antagonist WAY160103 (WAY) inhibits VCAM-1 activated eosinophil (EOS) respiratory burst but promotes eosinophil derived neurotoxin (EDN) degranulation

EOS are selectively recruited to the lung during asthma exacerbations and play an important role in airway inflammation. EOS participation is initiated by adhesion of circulating cells via VLA-4 (a4β1) to VCAM-1 expressed on pulmonary endothelium. Inhibition of this process has been studied with a v...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2004-02, Vol.113 (2), p.S324-S324
Hauptverfasser:	Brooks, A.M., Sedgwick, J.B., Jansen, K.J., Kita, H., Squillace, D., Kennedy, J.D., Busse, W.W.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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