Mast cells in the innate immune response of the middle ear

New pathophysiologic concepts are needed to explain the clinically observed connection between the allergic diathesis and otitis media (OM). Since mast cells are the only leucocytes present in substantial numbers in the normal middle ear mucosa and are known to participate in innate immunity, we exa...

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Veröffentlicht in:Journal of allergy and clinical immunology 2005-02, Vol.115 (2), p.S187-S187
Hauptverfasser: Ebmeyer, J., Furukawa, M., Pak, K.K., Ebmeyer, U., Sudhoff, H.H., Broide, D.H., Ryan, A.F., Wasserman, S.I.
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container_end_page S187
container_issue 2
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container_title Journal of allergy and clinical immunology
container_volume 115
creator Ebmeyer, J.
Furukawa, M.
Pak, K.K.
Ebmeyer, U.
Sudhoff, H.H.
Broide, D.H.
Ryan, A.F.
Wasserman, S.I.
description New pathophysiologic concepts are needed to explain the clinically observed connection between the allergic diathesis and otitis media (OM). Since mast cells are the only leucocytes present in substantial numbers in the normal middle ear mucosa and are known to participate in innate immunity, we examined their contributions to the pathogenesis of OM.
doi_str_mv 10.1016/j.jaci.2004.12.761
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subjects Cytokines
Ear diseases
Immune system
Pathogenesis
Rodents
title Mast cells in the innate immune response of the middle ear
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