Clinical and entomological factors influence the outcome of sting challenge studies
The reported frequency of systemic reactions to challenge sting varies greatly. To evaluate the interaction of clinical and entomological factors that determine the outcome of a challenge sting. Patients allergic to yellow jacket were stung and monitored for systemic reaction. The frequency and seve...
Gespeichert in:
| Veröffentlicht in: | Journal of allergy and clinical immunology 2006-03, Vol.117 (3), p.670-675 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 675 |
|---|---|
| container_issue | 3 |
| container_start_page | 670 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 117 |
| creator | Golden, David B.K. Breisch, Nancy L. Hamilton, Robert G. Guralnick, Miles W. Greene, Albert Craig, Timothy J. Kagey-Sobotka, Anne |
| description | The reported frequency of systemic reactions to challenge sting varies greatly.
To evaluate the interaction of clinical and entomological factors that determine the outcome of a challenge sting.
Patients allergic to yellow jacket were stung and monitored for systemic reaction. The frequency and severity of sting reactions were analyzed in relation to the species of insect used and patient characteristics.
Objective systemic reactions occurred in 21 of 69 patients (30%) stung with
Vespula maculifrons and in 8 of 71 patients (11%) with
Vespula germanica (
P = .005). Systemic reactions were more frequent in patients with a severe history (9/30; 30%) than in those with a mild or moderate history (21/145; 14%;
P = .04). In only 1 of 111 patients (0.9%) was the reaction to sting challenge more severe than previous reactions. The reaction rate was higher when venom skin tests were positive at |
| doi_str_mv | 10.1016/j.jaci.2005.12.1313 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1504746040</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091674905040340</els_id><sourcerecordid>3238986801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c460t-dd1639f8b752a188e9c0a7eb0ab4ce6be55524e3635ae184823c0fc8b576f9023</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVIyW62-QWFYig52tWHJVuHHsqSNoWFHpqehSyPdmW80layC_n3kbMLueU0zPDMO8OD0CeCK4KJ-DpUgzauohjzitCKMMKu0Jpg2ZSipfwarTGWpBRNLVfoNqUB55618gatiOCU1kKu0Z_t6Lwzeiy07wvwUziGMexfJ1abKcRUOG_HGbyBYjpAEebJhGOutkiT8_vCHPQ4gt9D7ufeQfqIPlg9Jri71A36--PhaftY7n7__LX9vitNLfBU9j0RTNq2azjVpG1BGqwb6LDuagOiA845rYEJxjWQtm4pM9iatuONsBJTtkFfzrmnGP7NkCY1hDn6fFIRjusmX6lxptiZMjGkFMGqU3RHHZ8VwWoRqQa1iFSLSEWoWkTmrc-X7Lk7Qv-2czGXgfsLoFOWZaP2xqU3rhGkoXIJ-nbmIJv47yCqZNwis3cRzKT64N595AUFCZFQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504746040</pqid></control><display><type>article</type><title>Clinical and entomological factors influence the outcome of sting challenge studies</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Golden, David B.K. ; Breisch, Nancy L. ; Hamilton, Robert G. ; Guralnick, Miles W. ; Greene, Albert ; Craig, Timothy J. ; Kagey-Sobotka, Anne</creator><creatorcontrib>Golden, David B.K. ; Breisch, Nancy L. ; Hamilton, Robert G. ; Guralnick, Miles W. ; Greene, Albert ; Craig, Timothy J. ; Kagey-Sobotka, Anne</creatorcontrib><description>The reported frequency of systemic reactions to challenge sting varies greatly.
To evaluate the interaction of clinical and entomological factors that determine the outcome of a challenge sting.
Patients allergic to yellow jacket were stung and monitored for systemic reaction. The frequency and severity of sting reactions were analyzed in relation to the species of insect used and patient characteristics.
Objective systemic reactions occurred in 21 of 69 patients (30%) stung with
Vespula maculifrons and in 8 of 71 patients (11%) with
Vespula germanica (
P = .005). Systemic reactions were more frequent in patients with a severe history (9/30; 30%) than in those with a mild or moderate history (21/145; 14%;
P = .04). In only 1 of 111 patients (0.9%) was the reaction to sting challenge more severe than previous reactions. The reaction rate was higher when venom skin tests were positive at <1.0 μg/mL (17/75 = 23%) than when sensitivity was milder (9/100 = 9%;
P = .012). We compared sting outcome and venom-induced histamine release in relation to insects collected in July or in October, and found no difference.
Allergic reactions to sting challenge are determined by the species of yellow jacket used, the severity of previous sting reactions, and the degree of skin test sensitivity, but not by the time of year. These factors are important to clinicians when they evaluate the chance of reaction to a future sting and to researchers when they design and report sting challenge studies.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2005.12.1313</identifier><identifier>PMID: 16522469</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Allergies ; anaphylaxis ; Animals ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Hymenoptera ; Hypersensitivity, Immediate - immunology ; Immunologic Tests ; Immunopathology ; Insect Bites and Stings - immunology ; insect sting ; insect venom ; Male ; Medical sciences ; Medical treatment ; Middle Aged ; Patients ; Skin Tests ; Sting challenge ; Studies ; Venom ; Wasps - immunology</subject><ispartof>Journal of allergy and clinical immunology, 2006-03, Vol.117 (3), p.670-675</ispartof><rights>2006 American Academy of Allergy, Asthma and Immunology</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Mar 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-dd1639f8b752a188e9c0a7eb0ab4ce6be55524e3635ae184823c0fc8b576f9023</citedby><cites>FETCH-LOGICAL-c460t-dd1639f8b752a188e9c0a7eb0ab4ce6be55524e3635ae184823c0fc8b576f9023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674905040340$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17617293$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16522469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Golden, David B.K.</creatorcontrib><creatorcontrib>Breisch, Nancy L.</creatorcontrib><creatorcontrib>Hamilton, Robert G.</creatorcontrib><creatorcontrib>Guralnick, Miles W.</creatorcontrib><creatorcontrib>Greene, Albert</creatorcontrib><creatorcontrib>Craig, Timothy J.</creatorcontrib><creatorcontrib>Kagey-Sobotka, Anne</creatorcontrib><title>Clinical and entomological factors influence the outcome of sting challenge studies</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>The reported frequency of systemic reactions to challenge sting varies greatly.
To evaluate the interaction of clinical and entomological factors that determine the outcome of a challenge sting.
Patients allergic to yellow jacket were stung and monitored for systemic reaction. The frequency and severity of sting reactions were analyzed in relation to the species of insect used and patient characteristics.
Objective systemic reactions occurred in 21 of 69 patients (30%) stung with
Vespula maculifrons and in 8 of 71 patients (11%) with
Vespula germanica (
P = .005). Systemic reactions were more frequent in patients with a severe history (9/30; 30%) than in those with a mild or moderate history (21/145; 14%;
P = .04). In only 1 of 111 patients (0.9%) was the reaction to sting challenge more severe than previous reactions. The reaction rate was higher when venom skin tests were positive at <1.0 μg/mL (17/75 = 23%) than when sensitivity was milder (9/100 = 9%;
P = .012). We compared sting outcome and venom-induced histamine release in relation to insects collected in July or in October, and found no difference.
Allergic reactions to sting challenge are determined by the species of yellow jacket used, the severity of previous sting reactions, and the degree of skin test sensitivity, but not by the time of year. These factors are important to clinicians when they evaluate the chance of reaction to a future sting and to researchers when they design and report sting challenge studies.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergies</subject><subject>anaphylaxis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Hymenoptera</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunologic Tests</subject><subject>Immunopathology</subject><subject>Insect Bites and Stings - immunology</subject><subject>insect sting</subject><subject>insect venom</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Skin Tests</subject><subject>Sting challenge</subject><subject>Studies</subject><subject>Venom</subject><subject>Wasps - immunology</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVIyW62-QWFYig52tWHJVuHHsqSNoWFHpqehSyPdmW80layC_n3kbMLueU0zPDMO8OD0CeCK4KJ-DpUgzauohjzitCKMMKu0Jpg2ZSipfwarTGWpBRNLVfoNqUB55618gatiOCU1kKu0Z_t6Lwzeiy07wvwUziGMexfJ1abKcRUOG_HGbyBYjpAEebJhGOutkiT8_vCHPQ4gt9D7ufeQfqIPlg9Jri71A36--PhaftY7n7__LX9vitNLfBU9j0RTNq2azjVpG1BGqwb6LDuagOiA845rYEJxjWQtm4pM9iatuONsBJTtkFfzrmnGP7NkCY1hDn6fFIRjusmX6lxptiZMjGkFMGqU3RHHZ8VwWoRqQa1iFSLSEWoWkTmrc-X7Lk7Qv-2czGXgfsLoFOWZaP2xqU3rhGkoXIJ-nbmIJv47yCqZNwis3cRzKT64N595AUFCZFQ</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Golden, David B.K.</creator><creator>Breisch, Nancy L.</creator><creator>Hamilton, Robert G.</creator><creator>Guralnick, Miles W.</creator><creator>Greene, Albert</creator><creator>Craig, Timothy J.</creator><creator>Kagey-Sobotka, Anne</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20060301</creationdate><title>Clinical and entomological factors influence the outcome of sting challenge studies</title><author>Golden, David B.K. ; Breisch, Nancy L. ; Hamilton, Robert G. ; Guralnick, Miles W. ; Greene, Albert ; Craig, Timothy J. ; Kagey-Sobotka, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-dd1639f8b752a188e9c0a7eb0ab4ce6be55524e3635ae184823c0fc8b576f9023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allergies</topic><topic>anaphylaxis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Hymenoptera</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunologic Tests</topic><topic>Immunopathology</topic><topic>Insect Bites and Stings - immunology</topic><topic>insect sting</topic><topic>insect venom</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Skin Tests</topic><topic>Sting challenge</topic><topic>Studies</topic><topic>Venom</topic><topic>Wasps - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Golden, David B.K.</creatorcontrib><creatorcontrib>Breisch, Nancy L.</creatorcontrib><creatorcontrib>Hamilton, Robert G.</creatorcontrib><creatorcontrib>Guralnick, Miles W.</creatorcontrib><creatorcontrib>Greene, Albert</creatorcontrib><creatorcontrib>Craig, Timothy J.</creatorcontrib><creatorcontrib>Kagey-Sobotka, Anne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golden, David B.K.</au><au>Breisch, Nancy L.</au><au>Hamilton, Robert G.</au><au>Guralnick, Miles W.</au><au>Greene, Albert</au><au>Craig, Timothy J.</au><au>Kagey-Sobotka, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and entomological factors influence the outcome of sting challenge studies</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>117</volume><issue>3</issue><spage>670</spage><epage>675</epage><pages>670-675</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>The reported frequency of systemic reactions to challenge sting varies greatly.
To evaluate the interaction of clinical and entomological factors that determine the outcome of a challenge sting.
Patients allergic to yellow jacket were stung and monitored for systemic reaction. The frequency and severity of sting reactions were analyzed in relation to the species of insect used and patient characteristics.
Objective systemic reactions occurred in 21 of 69 patients (30%) stung with
Vespula maculifrons and in 8 of 71 patients (11%) with
Vespula germanica (
P = .005). Systemic reactions were more frequent in patients with a severe history (9/30; 30%) than in those with a mild or moderate history (21/145; 14%;
P = .04). In only 1 of 111 patients (0.9%) was the reaction to sting challenge more severe than previous reactions. The reaction rate was higher when venom skin tests were positive at <1.0 μg/mL (17/75 = 23%) than when sensitivity was milder (9/100 = 9%;
P = .012). We compared sting outcome and venom-induced histamine release in relation to insects collected in July or in October, and found no difference.
Allergic reactions to sting challenge are determined by the species of yellow jacket used, the severity of previous sting reactions, and the degree of skin test sensitivity, but not by the time of year. These factors are important to clinicians when they evaluate the chance of reaction to a future sting and to researchers when they design and report sting challenge studies.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>16522469</pmid><doi>10.1016/j.jaci.2005.12.1313</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2006-03, Vol.117 (3), p.670-675 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_proquest_journals_1504746040 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Allergies anaphylaxis Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hymenoptera Hypersensitivity, Immediate - immunology Immunologic Tests Immunopathology Insect Bites and Stings - immunology insect sting insect venom Male Medical sciences Medical treatment Middle Aged Patients Skin Tests Sting challenge Studies Venom Wasps - immunology |
| title | Clinical and entomological factors influence the outcome of sting challenge studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T14%3A50%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20and%20entomological%20factors%20influence%20the%20outcome%20of%20sting%20challenge%20studies&rft.jtitle=Journal%20of%20allergy%20and%20clinical%20immunology&rft.au=Golden,%20David%20B.K.&rft.date=2006-03-01&rft.volume=117&rft.issue=3&rft.spage=670&rft.epage=675&rft.pages=670-675&rft.issn=0091-6749&rft.eissn=1097-6825&rft.coden=JACIBY&rft_id=info:doi/10.1016/j.jaci.2005.12.1313&rft_dat=%3Cproquest_cross%3E3238986801%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1504746040&rft_id=info:pmid/16522469&rft_els_id=S0091674905040340&rfr_iscdi=true |