The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure

Inflammatory mediators play an important role in the pathogenesis of chronic heart failure (CHF). Methotrexate (MTX) is used in the treatment of inflammatory-mediated diseases (eg, rheumatoid arthritis) because it modulates the expression of numerous inflammatory cytokines. However, no studies have...

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Veröffentlicht in:	The American heart journal 2006, Vol.151 (1), p.62-68
Hauptverfasser:	Gong, Kaizheng, Zhang, Zhengang, Sun, Xiaonin, Zhang, Xin, Li, Aihua, Yan, Junfeng, Luo, Qiuping, Gao, Yang, Feng, Yiliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Angina pectoris Anti-Inflammatory Agents - adverse effects Anti-Inflammatory Agents - therapeutic use Cardiovascular disease Chronic Disease Cytokines Cytokines - blood Drug therapy Female Heart attacks Heart Failure - blood Heart Failure - drug therapy Humans Inflammation Mediators - blood Male Methotrexate - adverse effects Methotrexate - therapeutic use Middle Aged Prospective Studies Single-Blind Method
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