S1P1 Receptor Signaling Overrides Retention Mediated by G[alpha]i-Coupled Receptors to Promote T Cell Egress

The mechanism by which sphingosine-1-phosphate receptor-1 (S1P1) acts to promote lymphocyte egress from lymphoid organs is not defined. Here, we showed that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells did, whereas CCR7-overexpressing cells were retained for longer. Afte...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2008-01, Vol.28 (1), p.122
Hauptverfasser:	Pham, Trung HM, Okada, Takaharu, Matloubian, Mehrdad, Lo, Charles G, Cyster, Jason G
Format:	Artikel
Sprache:	eng
Schlagworte:	Cloning Colleges & universities Flow cytometry Ligands Lymphatic system Lymphocytes Retention Rodents
Online-Zugang:	Volltext
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