DOCK2 Is Essential for Antigen-Induced Translocation of TCR and Lipid Rafts, but Not PKC-[theta] and LFA-1, in T Cells

DOCK2 is a mammalian homolog ofCaenorhabditis elegansCED-5 andDrosophila melanogasterMyoblast City which are known to regulate actin cytoskeleton. DOCK2 is critical for lymphocyte migration, yet the role of DOCK2 in TCR signaling remains unclear. We show here that DOCK2 is essential for TCR-mediated...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2003-07, Vol.19 (1), p.119
Hauptverfasser:	Sanui, Terukazu, Inayoshi, Ayumi, Noda, Mayuko, Iwata, Eiko, Oike, Masahiro, Sasazuki, Takehiko, Fukui, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell growth Chemokines Cytoskeleton Kinases Lipids Lymphocytes Microscopy Peptides Phosphorylation Proteins Rodents T cell receptors
Online-Zugang:	Volltext
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