Role of [beta]-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly
Cadherins and catenins are thought to promote adhesion between pre and postsynaptic elements in the brain. Here we show a role for β-catenin in localizing the reserved pool of vesicles at presynaptic sites. Deletion of β-catenin in hippocampal pyramidal neurons in vivo resulted in a reduction in the...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2003-11, Vol.40 (4), p.719 |
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| creator | Bamji, Shernaz X Shimazu, Kazuhiro Kimes, Nikole Huelsken, Joerg Birchmeier, Walter Lu, Bai Reichardt, Louis F |
| description | Cadherins and catenins are thought to promote adhesion between pre and postsynaptic elements in the brain. Here we show a role for β-catenin in localizing the reserved pool of vesicles at presynaptic sites. Deletion of β-catenin in hippocampal pyramidal neurons in vivo resulted in a reduction in the number of reserved pool vesicles per synapse and an impaired response to prolonged repetitive stimulation. This corresponded to a dispersion of vesicles along the axon in cultured neurons. Interestingly, these effects are not due to β-catenin's involvement in cadherin-mediated adhesion or wnt signaling. Instead, β-catenin modulates vesicle localization via its PDZ binding domain to recruit PDZ proteins such as Veli to cadherin at synapses. This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion. |
| doi_str_mv | 10.1016/S0896-6273(03)00718-9 |
| format | Article |
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| source | Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Binding sites Cell adhesion & migration Cytoskeleton Kinases Proteins Software |
| title | Role of [beta]-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly |
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