Leptin hormone level in serum of opticospinal, neuromyelitisoptica and multiple sclerosis patients
Objectives A growing body of evidence shows that leptin acts as a pro‐inflammatory cytokine in autoimmune disorders and is related to multiple sclerosis (MS) pathogenesis. The present study was an analysis of serum leptin levels among healthy volunteers and patients with different subtypes of MS, op...
Gespeichert in:
| Veröffentlicht in: | Clinical & experimental neuroimmunology 2014-02, Vol.5 (1), p.77-83 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 83 |
|---|---|
| container_issue | 1 |
| container_start_page | 77 |
| container_title | Clinical & experimental neuroimmunology |
| container_volume | 5 |
| creator | Bahrami, Ehsan Zarkesh-Esfahani, Sayyed Hamid Kardi, Mohammad T. Mostajeran, Maryam Triot, Alexa Bouzari, Majid Maghzi, Amir H. Etemadifar, Masoud |
| description | Objectives
A growing body of evidence shows that leptin acts as a pro‐inflammatory cytokine in autoimmune disorders and is related to multiple sclerosis (MS) pathogenesis. The present study was an analysis of serum leptin levels among healthy volunteers and patients with different subtypes of MS, opticospinal MS (OSMS) and neuromyelitis optica (NMO).
Methods
Leptin concentrations in the sera of 121 healthy volunteers and 201 patients with different subtypes of MS, as well as in 27 NMO and 27 OSMS, were measured.
Results
Significant differences in leptin serum levels were observed between healthy volunteers, and MS, OSMS and NMO patients (P |
| doi_str_mv | 10.1111/cen3.12092 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1502879050</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3231818081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3142-9a7bb8ef4f934e97c0844289fc906fd73ba8a014f94644118d725113cdb6a2ca3</originalsourceid><addsrcrecordid>eNp9kEFLxDAQhYsoKLoXf0HAm1hNmrRJjrK6KiwqongMaXaK0bSpSavuvzfrqnhyLjPM-94wvCzbJ_iYpDox0NFjUmBZbGQ7hJcyJ7Iim3_m7WwS4zNORYVgnO1k9Rz6wXboyYfWd4AcvIFDaREhjC3yDfJJNz72ttPuCHUwBt8uwdnBxi9JI90tUDu6wfYOUDQOgo82ol4PFroh7mVbjXYRJt99N3uYnd9PL_P5zcXV9HSeG0pYkUvN61pAwxpJGUhusGCsELIxElfNgtNaC41JklnFGCFiwYuSEGoWdaULo-ludrC-2wf_OkIc1LMfQ_o6KlLiQnCJS5yowzVl0pcxQKP6YFsdlopgtYpRrWJUXzEmmKzhd-tg-Q-ppufX9MeTrz02DvDx69HhRVWc8lI9Xl-oyzM6m93dFkrQT-thhGc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1502879050</pqid></control><display><type>article</type><title>Leptin hormone level in serum of opticospinal, neuromyelitisoptica and multiple sclerosis patients</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bahrami, Ehsan ; Zarkesh-Esfahani, Sayyed Hamid ; Kardi, Mohammad T. ; Mostajeran, Maryam ; Triot, Alexa ; Bouzari, Majid ; Maghzi, Amir H. ; Etemadifar, Masoud</creator><creatorcontrib>Bahrami, Ehsan ; Zarkesh-Esfahani, Sayyed Hamid ; Kardi, Mohammad T. ; Mostajeran, Maryam ; Triot, Alexa ; Bouzari, Majid ; Maghzi, Amir H. ; Etemadifar, Masoud</creatorcontrib><description>Objectives
A growing body of evidence shows that leptin acts as a pro‐inflammatory cytokine in autoimmune disorders and is related to multiple sclerosis (MS) pathogenesis. The present study was an analysis of serum leptin levels among healthy volunteers and patients with different subtypes of MS, opticospinal MS (OSMS) and neuromyelitis optica (NMO).
Methods
Leptin concentrations in the sera of 121 healthy volunteers and 201 patients with different subtypes of MS, as well as in 27 NMO and 27 OSMS, were measured.
Results
Significant differences in leptin serum levels were observed between healthy volunteers, and MS, OSMS and NMO patients (P < 0.001). Furthermore, leptin serum concentration was in correlation with expanded disability status scale (EDSS) in primary progressive MS and secondary progressive MS groups. Interestingly, while the female‐to‐male ratio of leptin was approximately 2 in each group, the NMO female patients showed sevenfold higher levels of leptin than males.
Conclusion
The present results show that leptin concentration is important in the pathogenesis of different neuroinflammatory diseases of the central nervous system, in particular NMO.</description><identifier>ISSN: 1759-1961</identifier><identifier>EISSN: 1759-1961</identifier><identifier>DOI: 10.1111/cen3.12092</identifier><language>eng</language><publisher>Ube: Blackwell Publishing Ltd</publisher><subject>leptin ; multiple sclerosis ; neuromyelitisoptica ; opticospinal</subject><ispartof>Clinical & experimental neuroimmunology, 2014-02, Vol.5 (1), p.77-83</ispartof><rights>2014 Japanese Society for Neuroimmunology</rights><rights>Copyright © 2014 Japanese Society for Neuroimmunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3142-9a7bb8ef4f934e97c0844289fc906fd73ba8a014f94644118d725113cdb6a2ca3</citedby><cites>FETCH-LOGICAL-c3142-9a7bb8ef4f934e97c0844289fc906fd73ba8a014f94644118d725113cdb6a2ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen3.12092$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen3.12092$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Bahrami, Ehsan</creatorcontrib><creatorcontrib>Zarkesh-Esfahani, Sayyed Hamid</creatorcontrib><creatorcontrib>Kardi, Mohammad T.</creatorcontrib><creatorcontrib>Mostajeran, Maryam</creatorcontrib><creatorcontrib>Triot, Alexa</creatorcontrib><creatorcontrib>Bouzari, Majid</creatorcontrib><creatorcontrib>Maghzi, Amir H.</creatorcontrib><creatorcontrib>Etemadifar, Masoud</creatorcontrib><title>Leptin hormone level in serum of opticospinal, neuromyelitisoptica and multiple sclerosis patients</title><title>Clinical & experimental neuroimmunology</title><addtitle>Clin Exp Neuroimmunol</addtitle><description>Objectives
A growing body of evidence shows that leptin acts as a pro‐inflammatory cytokine in autoimmune disorders and is related to multiple sclerosis (MS) pathogenesis. The present study was an analysis of serum leptin levels among healthy volunteers and patients with different subtypes of MS, opticospinal MS (OSMS) and neuromyelitis optica (NMO).
Methods
Leptin concentrations in the sera of 121 healthy volunteers and 201 patients with different subtypes of MS, as well as in 27 NMO and 27 OSMS, were measured.
Results
Significant differences in leptin serum levels were observed between healthy volunteers, and MS, OSMS and NMO patients (P < 0.001). Furthermore, leptin serum concentration was in correlation with expanded disability status scale (EDSS) in primary progressive MS and secondary progressive MS groups. Interestingly, while the female‐to‐male ratio of leptin was approximately 2 in each group, the NMO female patients showed sevenfold higher levels of leptin than males.
Conclusion
The present results show that leptin concentration is important in the pathogenesis of different neuroinflammatory diseases of the central nervous system, in particular NMO.</description><subject>leptin</subject><subject>multiple sclerosis</subject><subject>neuromyelitisoptica</subject><subject>opticospinal</subject><issn>1759-1961</issn><issn>1759-1961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLxDAQhYsoKLoXf0HAm1hNmrRJjrK6KiwqongMaXaK0bSpSavuvzfrqnhyLjPM-94wvCzbJ_iYpDox0NFjUmBZbGQ7hJcyJ7Iim3_m7WwS4zNORYVgnO1k9Rz6wXboyYfWd4AcvIFDaREhjC3yDfJJNz72ttPuCHUwBt8uwdnBxi9JI90tUDu6wfYOUDQOgo82ol4PFroh7mVbjXYRJt99N3uYnd9PL_P5zcXV9HSeG0pYkUvN61pAwxpJGUhusGCsELIxElfNgtNaC41JklnFGCFiwYuSEGoWdaULo-ludrC-2wf_OkIc1LMfQ_o6KlLiQnCJS5yowzVl0pcxQKP6YFsdlopgtYpRrWJUXzEmmKzhd-tg-Q-ppufX9MeTrz02DvDx69HhRVWc8lI9Xl-oyzM6m93dFkrQT-thhGc</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Bahrami, Ehsan</creator><creator>Zarkesh-Esfahani, Sayyed Hamid</creator><creator>Kardi, Mohammad T.</creator><creator>Mostajeran, Maryam</creator><creator>Triot, Alexa</creator><creator>Bouzari, Majid</creator><creator>Maghzi, Amir H.</creator><creator>Etemadifar, Masoud</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201402</creationdate><title>Leptin hormone level in serum of opticospinal, neuromyelitisoptica and multiple sclerosis patients</title><author>Bahrami, Ehsan ; Zarkesh-Esfahani, Sayyed Hamid ; Kardi, Mohammad T. ; Mostajeran, Maryam ; Triot, Alexa ; Bouzari, Majid ; Maghzi, Amir H. ; Etemadifar, Masoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3142-9a7bb8ef4f934e97c0844289fc906fd73ba8a014f94644118d725113cdb6a2ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>leptin</topic><topic>multiple sclerosis</topic><topic>neuromyelitisoptica</topic><topic>opticospinal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahrami, Ehsan</creatorcontrib><creatorcontrib>Zarkesh-Esfahani, Sayyed Hamid</creatorcontrib><creatorcontrib>Kardi, Mohammad T.</creatorcontrib><creatorcontrib>Mostajeran, Maryam</creatorcontrib><creatorcontrib>Triot, Alexa</creatorcontrib><creatorcontrib>Bouzari, Majid</creatorcontrib><creatorcontrib>Maghzi, Amir H.</creatorcontrib><creatorcontrib>Etemadifar, Masoud</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Clinical & experimental neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahrami, Ehsan</au><au>Zarkesh-Esfahani, Sayyed Hamid</au><au>Kardi, Mohammad T.</au><au>Mostajeran, Maryam</au><au>Triot, Alexa</au><au>Bouzari, Majid</au><au>Maghzi, Amir H.</au><au>Etemadifar, Masoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin hormone level in serum of opticospinal, neuromyelitisoptica and multiple sclerosis patients</atitle><jtitle>Clinical & experimental neuroimmunology</jtitle><addtitle>Clin Exp Neuroimmunol</addtitle><date>2014-02</date><risdate>2014</risdate><volume>5</volume><issue>1</issue><spage>77</spage><epage>83</epage><pages>77-83</pages><issn>1759-1961</issn><eissn>1759-1961</eissn><abstract>Objectives
A growing body of evidence shows that leptin acts as a pro‐inflammatory cytokine in autoimmune disorders and is related to multiple sclerosis (MS) pathogenesis. The present study was an analysis of serum leptin levels among healthy volunteers and patients with different subtypes of MS, opticospinal MS (OSMS) and neuromyelitis optica (NMO).
Methods
Leptin concentrations in the sera of 121 healthy volunteers and 201 patients with different subtypes of MS, as well as in 27 NMO and 27 OSMS, were measured.
Results
Significant differences in leptin serum levels were observed between healthy volunteers, and MS, OSMS and NMO patients (P < 0.001). Furthermore, leptin serum concentration was in correlation with expanded disability status scale (EDSS) in primary progressive MS and secondary progressive MS groups. Interestingly, while the female‐to‐male ratio of leptin was approximately 2 in each group, the NMO female patients showed sevenfold higher levels of leptin than males.
Conclusion
The present results show that leptin concentration is important in the pathogenesis of different neuroinflammatory diseases of the central nervous system, in particular NMO.</abstract><cop>Ube</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1111/cen3.12092</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1759-1961 |
| ispartof | Clinical & experimental neuroimmunology, 2014-02, Vol.5 (1), p.77-83 |
| issn | 1759-1961 1759-1961 |
| language | eng |
| recordid | cdi_proquest_journals_1502879050 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | leptin multiple sclerosis neuromyelitisoptica opticospinal |
| title | Leptin hormone level in serum of opticospinal, neuromyelitisoptica and multiple sclerosis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T19%3A40%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptin%20hormone%20level%20in%20serum%20of%20opticospinal,%20neuromyelitisoptica%20and%20multiple%20sclerosis%20patients&rft.jtitle=Clinical%20&%20experimental%20neuroimmunology&rft.au=Bahrami,%20Ehsan&rft.date=2014-02&rft.volume=5&rft.issue=1&rft.spage=77&rft.epage=83&rft.pages=77-83&rft.issn=1759-1961&rft.eissn=1759-1961&rft_id=info:doi/10.1111/cen3.12092&rft_dat=%3Cproquest_cross%3E3231818081%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1502879050&rft_id=info:pmid/&rfr_iscdi=true |