In vitro 3D angiogenesis assay in egg white matrix: comparison to Matrigel, compatibility to various species, and suitability for drug testing

In vitro angiogenesis assays are commonly used to assess pro- or anti-angiogenic drug properties. Extracellular matrix (ECM) substitutes such as Matrigel and collagen gel became very popular in in vitro 3D angiogenesis assays as they enable tubule formation by endothelial cells from culture or aorti...

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Veröffentlicht in:	Laboratory investigation 2014-03, Vol.94 (3), p.340-349
Hauptverfasser:	Mousseau, Yoanne, Mollard, Séverine, Qiu, Hao, Richard, Laurence, Cazal, Raphael, Nizou, Angélique, Vedrenne, Nicolas, Rémi, Séverine, Baaj, Yasser, Fourcade, Laurent, Funalot, Benoit, Sturtz, Franck G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436 631/1647/1407 631/1647/767 angiogenesis assay Animals Animals, Genetically Modified Aorta, Thoracic - cytology aortic ring Bisbenzimidazole Coculture Techniques - methods Collagen Drug Combinations Drug Evaluation, Preclinical - methods Egg White endothelial cell Endothelial Cells - cytology Endothelial Cells - drug effects Fluorescent Dyes Human Umbilical Vein Endothelial Cells Humans Indoles Laboratory Medicine Laminin Medicine Medicine & Public Health Mice Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Neovascularization, Physiologic - drug effects original-article Pathology Proteoglycans Rats smooth muscle cell Species Specificity
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