Fast and delayed locomotor response to acute high-dose nicotine administration in adult male rats
The aim of the present study was to compare the immediate and delayed locomotor response to high-dose nicotine (NIC) administration in rats. The vertical and horizontal activity of behavior in adult male rats exposed to 1 mg/kg NIC or saline (SAL) were tested in a Laboras apparatus for one hour afte...
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| Veröffentlicht in: | Physiological research 2013-01, Vol.62 Suppl 1, p.S81-S88 |
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| description | The aim of the present study was to compare the immediate and delayed locomotor response to high-dose nicotine (NIC) administration in rats. The vertical and horizontal activity of behavior in adult male rats exposed to 1 mg/kg NIC or saline (SAL) were tested in a Laboras apparatus for one hour after drug application. Animals were then returned to their cages and housed for another seven days. After this period all animals were placed in Laboras again and their behavioral pattern was retested for another period of one hour (delayed response). Horizontal activity: immediately after nicotine administration animal were less mobile (first 2-minutes interval), when compared with controls. The immobilization effect of nicotine disappeared within 4 minutes and during whole first 10-minutes interval time spent by locomotion did not differ from controls. Locomotion activity of animals treated with nicotine increased robustly in following 10 minutes and remained significantly higher in 2nd, 3rd and 5th 10-minutes interval. Vertical activity: Rearing frequency was significantly lowered by NIC administration in first two minutes of the experiment and the same was found when the duration of rearing was analyzed. Lower rearing intensity of NIC treated animals disappeared in 4 minutes and was finally higher during whole test session as compared with controls. When duration of rearing was analyzed it was significantly longer in NIC treated animals. In majority of observed behavioral aspects there were no differences between NIC treated rats and controls seven days after NIC or SAL treatment. Our results reflect effect of NIC and we conclude that NIC significantly influences behavior of experimental animals. |
| doi_str_mv | 10.33549/physiolres.932610 |
| format | Article |
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The vertical and horizontal activity of behavior in adult male rats exposed to 1 mg/kg NIC or saline (SAL) were tested in a Laboras apparatus for one hour after drug application. Animals were then returned to their cages and housed for another seven days. After this period all animals were placed in Laboras again and their behavioral pattern was retested for another period of one hour (delayed response). Horizontal activity: immediately after nicotine administration animal were less mobile (first 2-minutes interval), when compared with controls. The immobilization effect of nicotine disappeared within 4 minutes and during whole first 10-minutes interval time spent by locomotion did not differ from controls. Locomotion activity of animals treated with nicotine increased robustly in following 10 minutes and remained significantly higher in 2nd, 3rd and 5th 10-minutes interval. Vertical activity: Rearing frequency was significantly lowered by NIC administration in first two minutes of the experiment and the same was found when the duration of rearing was analyzed. Lower rearing intensity of NIC treated animals disappeared in 4 minutes and was finally higher during whole test session as compared with controls. When duration of rearing was analyzed it was significantly longer in NIC treated animals. In majority of observed behavioral aspects there were no differences between NIC treated rats and controls seven days after NIC or SAL treatment. Our results reflect effect of NIC and we conclude that NIC significantly influences behavior of experimental animals.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.932610</identifier><identifier>PMID: 24329707</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Animal behavior ; Animals ; Automation ; Behavior, Animal - physiology ; Behavior, Animal - radiation effects ; Dopamine ; Drug dosages ; Experiments ; Gait - physiology ; Gait - radiation effects ; Habituation, Psychophysiologic - drug effects ; Habituation, Psychophysiologic - physiology ; Locomotion - physiology ; Locomotion - radiation effects ; Male ; Motor Activity - physiology ; Motor Activity - radiation effects ; Nicotine ; Nicotine - administration & dosage ; Rats ; Rats, Wistar ; Rodents ; Software</subject><ispartof>Physiological research, 2013-01, Vol.62 Suppl 1, p.S81-S88</ispartof><rights>Copyright Institute of Physiology 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-4b1de3f73e732aee409aaa27be2fd1e6a5aef54583e3e439261c6d725865b7753</citedby><cites>FETCH-LOGICAL-c342t-4b1de3f73e732aee409aaa27be2fd1e6a5aef54583e3e439261c6d725865b7753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24329707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jandová, K</creatorcontrib><creatorcontrib>Marešová, D</creatorcontrib><creatorcontrib>Pokorný, J</creatorcontrib><title>Fast and delayed locomotor response to acute high-dose nicotine administration in adult male rats</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>The aim of the present study was to compare the immediate and delayed locomotor response to high-dose nicotine (NIC) administration in rats. The vertical and horizontal activity of behavior in adult male rats exposed to 1 mg/kg NIC or saline (SAL) were tested in a Laboras apparatus for one hour after drug application. Animals were then returned to their cages and housed for another seven days. After this period all animals were placed in Laboras again and their behavioral pattern was retested for another period of one hour (delayed response). Horizontal activity: immediately after nicotine administration animal were less mobile (first 2-minutes interval), when compared with controls. The immobilization effect of nicotine disappeared within 4 minutes and during whole first 10-minutes interval time spent by locomotion did not differ from controls. Locomotion activity of animals treated with nicotine increased robustly in following 10 minutes and remained significantly higher in 2nd, 3rd and 5th 10-minutes interval. Vertical activity: Rearing frequency was significantly lowered by NIC administration in first two minutes of the experiment and the same was found when the duration of rearing was analyzed. Lower rearing intensity of NIC treated animals disappeared in 4 minutes and was finally higher during whole test session as compared with controls. When duration of rearing was analyzed it was significantly longer in NIC treated animals. In majority of observed behavioral aspects there were no differences between NIC treated rats and controls seven days after NIC or SAL treatment. 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Marešová, D ; Pokorný, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-4b1de3f73e732aee409aaa27be2fd1e6a5aef54583e3e439261c6d725865b7753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animal behavior</topic><topic>Animals</topic><topic>Automation</topic><topic>Behavior, Animal - physiology</topic><topic>Behavior, Animal - radiation effects</topic><topic>Dopamine</topic><topic>Drug dosages</topic><topic>Experiments</topic><topic>Gait - physiology</topic><topic>Gait - radiation effects</topic><topic>Habituation, Psychophysiologic - drug effects</topic><topic>Habituation, Psychophysiologic - physiology</topic><topic>Locomotion - physiology</topic><topic>Locomotion - radiation effects</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Motor Activity - radiation effects</topic><topic>Nicotine</topic><topic>Nicotine - administration & dosage</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jandová, K</creatorcontrib><creatorcontrib>Marešová, D</creatorcontrib><creatorcontrib>Pokorný, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jandová, K</au><au>Marešová, D</au><au>Pokorný, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fast and delayed locomotor response to acute high-dose nicotine administration in adult male rats</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>62 Suppl 1</volume><spage>S81</spage><epage>S88</epage><pages>S81-S88</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>The aim of the present study was to compare the immediate and delayed locomotor response to high-dose nicotine (NIC) administration in rats. The vertical and horizontal activity of behavior in adult male rats exposed to 1 mg/kg NIC or saline (SAL) were tested in a Laboras apparatus for one hour after drug application. Animals were then returned to their cages and housed for another seven days. After this period all animals were placed in Laboras again and their behavioral pattern was retested for another period of one hour (delayed response). Horizontal activity: immediately after nicotine administration animal were less mobile (first 2-minutes interval), when compared with controls. The immobilization effect of nicotine disappeared within 4 minutes and during whole first 10-minutes interval time spent by locomotion did not differ from controls. Locomotion activity of animals treated with nicotine increased robustly in following 10 minutes and remained significantly higher in 2nd, 3rd and 5th 10-minutes interval. Vertical activity: Rearing frequency was significantly lowered by NIC administration in first two minutes of the experiment and the same was found when the duration of rearing was analyzed. Lower rearing intensity of NIC treated animals disappeared in 4 minutes and was finally higher during whole test session as compared with controls. When duration of rearing was analyzed it was significantly longer in NIC treated animals. In majority of observed behavioral aspects there were no differences between NIC treated rats and controls seven days after NIC or SAL treatment. Our results reflect effect of NIC and we conclude that NIC significantly influences behavior of experimental animals.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>24329707</pmid><doi>10.33549/physiolres.932610</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Physiological research, 2013-01, Vol.62 Suppl 1, p.S81-S88 |
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| subjects | Animal behavior Animals Automation Behavior, Animal - physiology Behavior, Animal - radiation effects Dopamine Drug dosages Experiments Gait - physiology Gait - radiation effects Habituation, Psychophysiologic - drug effects Habituation, Psychophysiologic - physiology Locomotion - physiology Locomotion - radiation effects Male Motor Activity - physiology Motor Activity - radiation effects Nicotine Nicotine - administration & dosage Rats Rats, Wistar Rodents Software |
| title | Fast and delayed locomotor response to acute high-dose nicotine administration in adult male rats |
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