RUNX1 mutation associated with clonal evolution in relapsed pediatric acute myeloid leukemia with t(16;21)(p11;q22)

TLS/FUS - ERG chimeric fusion transcript resulting from translocation changes involving chromosomes 16 and 21 is a rare genetic event associated with acute myeloid leukemia (AML). The distinct t(16;21) AML subtype exhibits unique clinical and morphological features and is associated with poor progno...

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Veröffentlicht in:	International journal of hematology 2014-02, Vol.99 (2), p.169-174
Hauptverfasser:	Ismael, Olfat, Shimada, Akira, Elmahdi, Shaimaa, Elshazley, Momen, Muramatsu, Hideki, Hama, Asahito, Takahashi, Yoshiyuki, Yamada, Miho, Yamashita, Yuka, Horide, Keizo, Kojima, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Child Child, Preschool Chromosome aberrations Chromosomes, Human, Pair 16 Chromosomes, Human, Pair 21 Clonal Evolution Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism Female Hematologic and hematopoietic diseases Hematology Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical genetics Medical sciences Medicine Medicine & Public Health Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncology Original Article Recurrence RNA-Binding Protein FUS - genetics RNA-Binding Protein FUS - metabolism Translocation, Genetic Treatment Outcome
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