Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats
Colon cancer remains one of the major worldwide causes of cancer-related morbidity and mortality in Western countries and is increasingly common in Asia. Ellagic acid (EA), a major component of polyphenol possesses attractive remedial features. The aim of this study is to divulge the potential effec...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2014-03, Vol.388 (1-2), p.157-172 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 172 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 157 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 388 |
| creator | Umesalma, Syed Nagendraprabhu, Ponnuraj Sudhandiran, Ganapasam |
| description | Colon cancer remains one of the major worldwide causes of cancer-related morbidity and mortality in Western countries and is increasingly common in Asia. Ellagic acid (EA), a major component of polyphenol possesses attractive remedial features. The aim of this study is to divulge the potential effect of EA during 1,2-dimethyl hydrazine (DMH)-induced colon cancer in male Wistar albino rats. The rats were segregated into four groups: group I, control rats; group II, rats received EA (60 mg/kg b.wt./day, orally); rats in group III, induced with DMH (20 mg/kg b.wt.) subcutaneously for 15 weeks; DMH-induced group IV rats were initiated with EA treatment. Colon of the rats treated with DMH exhibited higher glycoconjugates and proliferation index such as elevated expressions of argyrophilic nucleolar organizing regions (AgNORs), proliferating cell nuclear antigen (PCNA), cyclin D1, matrix metalloproteins (MMP-2 and -9), and mast cells. DMH induction also increased phase I-metabolizing enzymes with simultaneous decrease in the phase II detoxifying enzymes. In contrast, dietary administration of EA significantly (
p
|
| doi_str_mv | 10.1007/s11010-013-1907-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1493987046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A364198289</galeid><sourcerecordid>A364198289</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-23b717882735f686dec4f0c25db9296cf2e363f9b0e0bf884636cd87b57422393</originalsourceid><addsrcrecordid>eNp1kdtqFTEUhoModrf6AN5IwFtTc5iZJJebUg9Q8EbxMmRymKbMJGOSLew-gw9tNlOLgrIuAivf_6-1-AF4RfAlwZi_K4RgghEmDBGJOcJPwI70nKFOEvkU7DDDGAnC-Rk4L-UONxgT8hyc0Y4KInqxAz_3sYY1pzl4l3UNPxzU0UK9prWmGgwK0R5MiBNcU3WN1TNMHrp51lMwUJvQ4EmHWCokbymyYXH19jjD26PN-j5Etzk4C02aU4T1sKQcJhddCQWGCL-FUnWGbXh5AZ55PRf38uG9AF_fX3-5-ohuPn_4dLW_QaZjsiLKRk64EJSz3g9isM50Hhva21FSORhPHRuYlyN2ePRCdAMbjBV87HlHKZPsArzZfNvh3w-uVHWXDjm2kYp0kknBcdM8UpOenQrRp5q1WUIxas-GjkhBxcnr8h9UK-uWYFJ0PrT-XwKyCUxOpWTn1ZrDovNREaxOsaotVtViVadYFW6a1w8LH8bF2UfF7xwbQDegtK84ufzHRf91_QUCq612</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1493987046</pqid></control><display><type>article</type><title>Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Umesalma, Syed ; Nagendraprabhu, Ponnuraj ; Sudhandiran, Ganapasam</creator><creatorcontrib>Umesalma, Syed ; Nagendraprabhu, Ponnuraj ; Sudhandiran, Ganapasam</creatorcontrib><description>Colon cancer remains one of the major worldwide causes of cancer-related morbidity and mortality in Western countries and is increasingly common in Asia. Ellagic acid (EA), a major component of polyphenol possesses attractive remedial features. The aim of this study is to divulge the potential effect of EA during 1,2-dimethyl hydrazine (DMH)-induced colon cancer in male Wistar albino rats. The rats were segregated into four groups: group I, control rats; group II, rats received EA (60 mg/kg b.wt./day, orally); rats in group III, induced with DMH (20 mg/kg b.wt.) subcutaneously for 15 weeks; DMH-induced group IV rats were initiated with EA treatment. Colon of the rats treated with DMH exhibited higher glycoconjugates and proliferation index such as elevated expressions of argyrophilic nucleolar organizing regions (AgNORs), proliferating cell nuclear antigen (PCNA), cyclin D1, matrix metalloproteins (MMP-2 and -9), and mast cells. DMH induction also increased phase I-metabolizing enzymes with simultaneous decrease in the phase II detoxifying enzymes. In contrast, dietary administration of EA significantly (
p
< 0.05) down regulated the proliferation index and restored back the levels of biotransformation enzymes. The carcinogenic insult also altered the expression of pro-apoptotic protein p53, whereas dietary EA administration significantly (
p
< 0.01) up regulates p53 expression to further induce apoptotic pathway. Ultrastructural changes in colon were also in accord with the above aberrations. Overall findings suggested that the suppression of colon cancer by EA in vivo involves inhibition of cell proliferation, activation of apoptosis, and efficient detoxification.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-013-1907-0</identifier><identifier>PMID: 24281858</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>1,2-Dimethylhydrazine ; Acids ; Animals ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Biotransformation ; Cardiology ; Cell Proliferation - drug effects ; Cell Transformation, Neoplastic - drug effects ; Colon ; Colon - pathology ; Colon cancer ; Colonic Neoplasms - chemically induced ; Colonic Neoplasms - drug therapy ; Cyclin D1 - biosynthesis ; Detoxification ; Ellagic acid ; Ellagic Acid - pharmacology ; Enzymes ; Health aspects ; Life Sciences ; Male ; Mast Cells - pathology ; Matrix Metalloproteinase 2 - biosynthesis ; Matrix Metalloproteinase 9 - biosynthesis ; Medical Biochemistry ; Oncology ; Proliferating Cell Nuclear Antigen - biosynthesis ; Rats ; Rats, Wistar ; Rodents ; Tumor proteins ; Tumor Suppressor Protein p53 - biosynthesis ; Tumors</subject><ispartof>Molecular and cellular biochemistry, 2014-03, Vol.388 (1-2), p.157-172</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2014 Springer</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-23b717882735f686dec4f0c25db9296cf2e363f9b0e0bf884636cd87b57422393</citedby><cites>FETCH-LOGICAL-c439t-23b717882735f686dec4f0c25db9296cf2e363f9b0e0bf884636cd87b57422393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-013-1907-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-013-1907-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24281858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Umesalma, Syed</creatorcontrib><creatorcontrib>Nagendraprabhu, Ponnuraj</creatorcontrib><creatorcontrib>Sudhandiran, Ganapasam</creatorcontrib><title>Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>Colon cancer remains one of the major worldwide causes of cancer-related morbidity and mortality in Western countries and is increasingly common in Asia. Ellagic acid (EA), a major component of polyphenol possesses attractive remedial features. The aim of this study is to divulge the potential effect of EA during 1,2-dimethyl hydrazine (DMH)-induced colon cancer in male Wistar albino rats. The rats were segregated into four groups: group I, control rats; group II, rats received EA (60 mg/kg b.wt./day, orally); rats in group III, induced with DMH (20 mg/kg b.wt.) subcutaneously for 15 weeks; DMH-induced group IV rats were initiated with EA treatment. Colon of the rats treated with DMH exhibited higher glycoconjugates and proliferation index such as elevated expressions of argyrophilic nucleolar organizing regions (AgNORs), proliferating cell nuclear antigen (PCNA), cyclin D1, matrix metalloproteins (MMP-2 and -9), and mast cells. DMH induction also increased phase I-metabolizing enzymes with simultaneous decrease in the phase II detoxifying enzymes. In contrast, dietary administration of EA significantly (
p
< 0.05) down regulated the proliferation index and restored back the levels of biotransformation enzymes. The carcinogenic insult also altered the expression of pro-apoptotic protein p53, whereas dietary EA administration significantly (
p
< 0.01) up regulates p53 expression to further induce apoptotic pathway. Ultrastructural changes in colon were also in accord with the above aberrations. Overall findings suggested that the suppression of colon cancer by EA in vivo involves inhibition of cell proliferation, activation of apoptosis, and efficient detoxification.</description><subject>1,2-Dimethylhydrazine</subject><subject>Acids</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotransformation</subject><subject>Cardiology</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Colon</subject><subject>Colon - pathology</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - chemically induced</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Cyclin D1 - biosynthesis</subject><subject>Detoxification</subject><subject>Ellagic acid</subject><subject>Ellagic Acid - pharmacology</subject><subject>Enzymes</subject><subject>Health aspects</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mast Cells - pathology</subject><subject>Matrix Metalloproteinase 2 - biosynthesis</subject><subject>Matrix Metalloproteinase 9 - biosynthesis</subject><subject>Medical Biochemistry</subject><subject>Oncology</subject><subject>Proliferating Cell Nuclear Antigen - biosynthesis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Tumor proteins</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumors</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kdtqFTEUhoModrf6AN5IwFtTc5iZJJebUg9Q8EbxMmRymKbMJGOSLew-gw9tNlOLgrIuAivf_6-1-AF4RfAlwZi_K4RgghEmDBGJOcJPwI70nKFOEvkU7DDDGAnC-Rk4L-UONxgT8hyc0Y4KInqxAz_3sYY1pzl4l3UNPxzU0UK9prWmGgwK0R5MiBNcU3WN1TNMHrp51lMwUJvQ4EmHWCokbymyYXH19jjD26PN-j5Etzk4C02aU4T1sKQcJhddCQWGCL-FUnWGbXh5AZ55PRf38uG9AF_fX3-5-ohuPn_4dLW_QaZjsiLKRk64EJSz3g9isM50Hhva21FSORhPHRuYlyN2ePRCdAMbjBV87HlHKZPsArzZfNvh3w-uVHWXDjm2kYp0kknBcdM8UpOenQrRp5q1WUIxas-GjkhBxcnr8h9UK-uWYFJ0PrT-XwKyCUxOpWTn1ZrDovNREaxOsaotVtViVadYFW6a1w8LH8bF2UfF7xwbQDegtK84ufzHRf91_QUCq612</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Umesalma, Syed</creator><creator>Nagendraprabhu, Ponnuraj</creator><creator>Sudhandiran, Ganapasam</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20140301</creationdate><title>Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats</title><author>Umesalma, Syed ; Nagendraprabhu, Ponnuraj ; Sudhandiran, Ganapasam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-23b717882735f686dec4f0c25db9296cf2e363f9b0e0bf884636cd87b57422393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>1,2-Dimethylhydrazine</topic><topic>Acids</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotransformation</topic><topic>Cardiology</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Colon</topic><topic>Colon - pathology</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - chemically induced</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Cyclin D1 - biosynthesis</topic><topic>Detoxification</topic><topic>Ellagic acid</topic><topic>Ellagic Acid - pharmacology</topic><topic>Enzymes</topic><topic>Health aspects</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Mast Cells - pathology</topic><topic>Matrix Metalloproteinase 2 - biosynthesis</topic><topic>Matrix Metalloproteinase 9 - biosynthesis</topic><topic>Medical Biochemistry</topic><topic>Oncology</topic><topic>Proliferating Cell Nuclear Antigen - biosynthesis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Tumor proteins</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Umesalma, Syed</creatorcontrib><creatorcontrib>Nagendraprabhu, Ponnuraj</creatorcontrib><creatorcontrib>Sudhandiran, Ganapasam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Umesalma, Syed</au><au>Nagendraprabhu, Ponnuraj</au><au>Sudhandiran, Ganapasam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>388</volume><issue>1-2</issue><spage>157</spage><epage>172</epage><pages>157-172</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Colon cancer remains one of the major worldwide causes of cancer-related morbidity and mortality in Western countries and is increasingly common in Asia. Ellagic acid (EA), a major component of polyphenol possesses attractive remedial features. The aim of this study is to divulge the potential effect of EA during 1,2-dimethyl hydrazine (DMH)-induced colon cancer in male Wistar albino rats. The rats were segregated into four groups: group I, control rats; group II, rats received EA (60 mg/kg b.wt./day, orally); rats in group III, induced with DMH (20 mg/kg b.wt.) subcutaneously for 15 weeks; DMH-induced group IV rats were initiated with EA treatment. Colon of the rats treated with DMH exhibited higher glycoconjugates and proliferation index such as elevated expressions of argyrophilic nucleolar organizing regions (AgNORs), proliferating cell nuclear antigen (PCNA), cyclin D1, matrix metalloproteins (MMP-2 and -9), and mast cells. DMH induction also increased phase I-metabolizing enzymes with simultaneous decrease in the phase II detoxifying enzymes. In contrast, dietary administration of EA significantly (
p
< 0.05) down regulated the proliferation index and restored back the levels of biotransformation enzymes. The carcinogenic insult also altered the expression of pro-apoptotic protein p53, whereas dietary EA administration significantly (
p
< 0.01) up regulates p53 expression to further induce apoptotic pathway. Ultrastructural changes in colon were also in accord with the above aberrations. Overall findings suggested that the suppression of colon cancer by EA in vivo involves inhibition of cell proliferation, activation of apoptosis, and efficient detoxification.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24281858</pmid><doi>10.1007/s11010-013-1907-0</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2014-03, Vol.388 (1-2), p.157-172 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_journals_1493987046 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 1,2-Dimethylhydrazine Acids Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Biotransformation Cardiology Cell Proliferation - drug effects Cell Transformation, Neoplastic - drug effects Colon Colon - pathology Colon cancer Colonic Neoplasms - chemically induced Colonic Neoplasms - drug therapy Cyclin D1 - biosynthesis Detoxification Ellagic acid Ellagic Acid - pharmacology Enzymes Health aspects Life Sciences Male Mast Cells - pathology Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Medical Biochemistry Oncology Proliferating Cell Nuclear Antigen - biosynthesis Rats Rats, Wistar Rodents Tumor proteins Tumor Suppressor Protein p53 - biosynthesis Tumors |
| title | Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T18%3A22%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antiproliferative%20and%20apoptotic-inducing%20potential%20of%20ellagic%20acid%20against%201,2-dimethyl%20hydrazine-induced%20colon%20tumorigenesis%20in%20Wistar%20rats&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Umesalma,%20Syed&rft.date=2014-03-01&rft.volume=388&rft.issue=1-2&rft.spage=157&rft.epage=172&rft.pages=157-172&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1007/s11010-013-1907-0&rft_dat=%3Cgale_proqu%3EA364198289%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1493987046&rft_id=info:pmid/24281858&rft_galeid=A364198289&rfr_iscdi=true |