Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice

Transforming growth factor beta (TGF‐β) signaling activates Smad‐ and TGF‐β‐activated kinase 1 (TAK1)‐dependent signaling to regulate cell survival, proliferation, fibrosis, and tumorigenesis. The effects of TGF‐β signaling on metabolic syndrome, including nonalcoholic fatty liver disease, remain el...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2014-02, Vol.59 (2), p.483-495
Hauptverfasser:	Yang, Ling, Roh, Yoon Seok, Song, Jingyi, Zhang, Bi, Liu, Cheng, Loomba, Rohit, Seki, Ekihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Cells, Cultured Choline Deficiency - metabolism Choline Deficiency - physiopathology Disease Models, Animal Disease Progression Fatty Liver - etiology Fatty Liver - pathology Fatty Liver - physiopathology Gene Deletion Gene expression Hepatocytes - pathology Hepatocytes - physiology Hepatology Kinases Lipid Metabolism - physiology Lipids Male Metabolism Mice Mice, Inbred C57BL Mice, Transgenic Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Reactive Oxygen Species - metabolism Receptors, Transforming Growth Factor beta - deficiency Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - physiology Rodents Signal Transduction - physiology Smad Proteins - physiology Transforming Growth Factor beta - physiology
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