Loss of Pgc-1[alpha] expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

Diabetes risk increases significantly with age and correlates with lower oxidative capacity in muscle. Decreased expression of peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc-1α) and target gene pathways involved in mitochondrial oxidative phosphorylation are associated with muscle...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2014-01, Vol.306 (2), p.E157
Hauptverfasser:	Sczelecki, Sarah, Besse-Patin, Aurèle, Abboud, Alexandra, Kleiner, Sandra, Laznik-Bogoslavski, Dina, Wrann, Christiane D, Ruas, Jorge L, Haibe-Kains, Benjamin, Estall, Jennifer L
Format:	Artikel
Sprache:	eng
Schlagworte:	Correlation analysis Diabetes Gene expression Glucose Insulin resistance Risk assessment Rodents
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