Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer

BACKGROUND The intervention of advanced prostate cancer (PCa) in patients has been commonly depending on androgen deprivation therapy. Despite of tremendous research efforts, however, molecular mechanisms on AR regulation remain poorly understood, particularly for castration resistant prostate cance...

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Veröffentlicht in:	The Prostate 2014-04, Vol.74 (4), p.421-432
Hauptverfasser:	Li, Bo, Lu, Wenfu, Yang, Qing, Yu, Xiuping, Matusik, Robert J., Chen, Zhenbang
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor (AR) Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Humans Imidazoles - pharmacology Male Phosphorylation - drug effects prostate cancer (PCa) Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-akt - metabolism Quinolines - pharmacology Receptors, Androgen - genetics Receptors, Androgen - metabolism S-Phase Kinase-Associated Proteins - genetics S-Phase Kinase-Associated Proteins - metabolism Signal Transduction - drug effects Skp2 TOR Serine-Threonine Kinases - metabolism Ubiquitin - metabolism ubiquitination Ubiquitination - drug effects
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