The Reverse-Direction Method Links Mass Experimental Data to Human Diseases
Genome-wide analyses such as DNA microarray, RNA sequencing and RNA interference-based high-throughput screening are prevalent to decipher a biological process of interest, and provide a large quantity of data to be processed. An ultimate goal for researchers must be extrapolation of their data to h...
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| Veröffentlicht in: | Archivum Immunologiae et Therapiae Experimentalis 2014-02, Vol.62 (1), p.41-45 |
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| container_title | Archivum Immunologiae et Therapiae Experimentalis |
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| creator | Ogura, Hideki Atsumi, Toru Bando, Hidenori Sabharwal, Lavannya Yamada, Moe Jiang, Jing-Jing Nakamura, Akihiro Arima, Yasunobu Kamimura, Daisuke Murakami, Masaaki |
| description | Genome-wide analyses such as DNA microarray, RNA sequencing and RNA interference-based high-throughput screening are prevalent to decipher a biological process of interest, and provide a large quantity of data to be processed. An ultimate goal for researchers must be extrapolation of their data to human diseases. We have conducted functional genome-wide screenings to elucidate molecular mechanisms of the inflammation amplifier, a NFκB/STAT3-dependent machinery that potently drives recruitment of immune cells to promote inflammation. Using a public database of genome-wide association studies (GWAS), we recently reported the reverse-direction method by which our mass screening data were successfully linked to many human diseases. As an example, the epiregulin–epidermal growth factor receptor pathway was identified as a regulator of the inflammation amplifier, and associated with human diseases by GWAS. In fact, serum epiregulin levels were higher in patients with chronic inflammatory disorders. The reverse-direction method can be a useful tool to narrow mass data down to focus on human disease-related genes. |
| doi_str_mv | 10.1007/s00005-013-0255-9 |
| format | Article |
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An ultimate goal for researchers must be extrapolation of their data to human diseases. We have conducted functional genome-wide screenings to elucidate molecular mechanisms of the inflammation amplifier, a NFκB/STAT3-dependent machinery that potently drives recruitment of immune cells to promote inflammation. Using a public database of genome-wide association studies (GWAS), we recently reported the reverse-direction method by which our mass screening data were successfully linked to many human diseases. As an example, the epiregulin–epidermal growth factor receptor pathway was identified as a regulator of the inflammation amplifier, and associated with human diseases by GWAS. In fact, serum epiregulin levels were higher in patients with chronic inflammatory disorders. The reverse-direction method can be a useful tool to narrow mass data down to focus on human disease-related genes.</description><identifier>ISSN: 0004-069X</identifier><identifier>EISSN: 1661-4917</identifier><identifier>DOI: 10.1007/s00005-013-0255-9</identifier><identifier>PMID: 23995916</identifier><language>eng</language><publisher>Basel: Springer Basel</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Movement ; Epidermal Growth Factor - genetics ; Epidermal Growth Factor - metabolism ; Epiregulin ; Genome-Wide Association Study ; High-Throughput Screening Assays ; Humans ; Immune System Diseases - diagnosis ; Immune System Diseases - immunology ; Immunology ; Inflammation Mediators - metabolism ; Mass Screening - methods ; Mass Screening - trends ; NF-kappa B - metabolism ; Pharmacology/Toxicology ; Receptor, Epidermal Growth Factor - genetics ; Receptor, Epidermal Growth Factor - metabolism ; Review ; Signal Transduction ; STAT3 Transcription Factor - metabolism ; Translational Medical Research</subject><ispartof>Archivum Immunologiae et Therapiae Experimentalis, 2014-02, Vol.62 (1), p.41-45</ispartof><rights>L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2013</rights><rights>L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-f36dbab530ae9ebb78fbdb881a86c3ac4cb7e3e7dd51a216da350ca3e4fc1e073</citedby><cites>FETCH-LOGICAL-c405t-f36dbab530ae9ebb78fbdb881a86c3ac4cb7e3e7dd51a216da350ca3e4fc1e073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00005-013-0255-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00005-013-0255-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23995916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogura, Hideki</creatorcontrib><creatorcontrib>Atsumi, Toru</creatorcontrib><creatorcontrib>Bando, Hidenori</creatorcontrib><creatorcontrib>Sabharwal, Lavannya</creatorcontrib><creatorcontrib>Yamada, Moe</creatorcontrib><creatorcontrib>Jiang, Jing-Jing</creatorcontrib><creatorcontrib>Nakamura, Akihiro</creatorcontrib><creatorcontrib>Arima, Yasunobu</creatorcontrib><creatorcontrib>Kamimura, Daisuke</creatorcontrib><creatorcontrib>Murakami, Masaaki</creatorcontrib><title>The Reverse-Direction Method Links Mass Experimental Data to Human Diseases</title><title>Archivum Immunologiae et Therapiae Experimentalis</title><addtitle>Arch. Immunol. Ther. Exp</addtitle><addtitle>Arch Immunol Ther Exp (Warsz)</addtitle><description>Genome-wide analyses such as DNA microarray, RNA sequencing and RNA interference-based high-throughput screening are prevalent to decipher a biological process of interest, and provide a large quantity of data to be processed. An ultimate goal for researchers must be extrapolation of their data to human diseases. We have conducted functional genome-wide screenings to elucidate molecular mechanisms of the inflammation amplifier, a NFκB/STAT3-dependent machinery that potently drives recruitment of immune cells to promote inflammation. Using a public database of genome-wide association studies (GWAS), we recently reported the reverse-direction method by which our mass screening data were successfully linked to many human diseases. 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The reverse-direction method can be a useful tool to narrow mass data down to focus on human disease-related genes.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Movement</subject><subject>Epidermal Growth Factor - genetics</subject><subject>Epidermal Growth Factor - metabolism</subject><subject>Epiregulin</subject><subject>Genome-Wide Association Study</subject><subject>High-Throughput Screening Assays</subject><subject>Humans</subject><subject>Immune System Diseases - diagnosis</subject><subject>Immune System Diseases - immunology</subject><subject>Immunology</subject><subject>Inflammation Mediators - metabolism</subject><subject>Mass Screening - methods</subject><subject>Mass Screening - trends</subject><subject>NF-kappa B - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>STAT3 Transcription Factor - metabolism</subject><subject>Translational Medical Research</subject><issn>0004-069X</issn><issn>1661-4917</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEFLAzEQhYMotlZ_gBcJeI4mm012c5S2WrFFkAreQpKdtVvb3Zrsiv57U1rFi3MZhnnz3vAhdM7oFaM0uw40liCUcUITIYg6QH0mJSOpYtkh6sdtSqhULz10EsIyTlyw9Bj1Eq6UUEz20cN8AfgJPsAHIKPKg2urpsYzaBdNgadV_RbwzISAx58b8NUa6tas8Mi0BrcNnnRrU-NRFcAECKfoqDSrAGf7PkDPt-P5cEKmj3f3w5spcSkVLSm5LKyxglMDCqzN8tIWNs-ZyaXjxqXOZsAhKwrBTMJkYbigznBIS8eAZnyALne-G9-8dxBavWw6X8dIzdJc8kQwIaKK7VTONyF4KPUm_m_8l2ZUb_HpHT4d8ektPq3izcXeubNrKH4vfnhFQbIThLiqX8H_if7X9RuLenrJ</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Ogura, Hideki</creator><creator>Atsumi, Toru</creator><creator>Bando, Hidenori</creator><creator>Sabharwal, Lavannya</creator><creator>Yamada, Moe</creator><creator>Jiang, Jing-Jing</creator><creator>Nakamura, Akihiro</creator><creator>Arima, Yasunobu</creator><creator>Kamimura, Daisuke</creator><creator>Murakami, Masaaki</creator><general>Springer Basel</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20140201</creationdate><title>The Reverse-Direction Method Links Mass Experimental Data to Human Diseases</title><author>Ogura, Hideki ; 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Immunol. Ther. Exp</stitle><addtitle>Arch Immunol Ther Exp (Warsz)</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>62</volume><issue>1</issue><spage>41</spage><epage>45</epage><pages>41-45</pages><issn>0004-069X</issn><eissn>1661-4917</eissn><abstract>Genome-wide analyses such as DNA microarray, RNA sequencing and RNA interference-based high-throughput screening are prevalent to decipher a biological process of interest, and provide a large quantity of data to be processed. An ultimate goal for researchers must be extrapolation of their data to human diseases. We have conducted functional genome-wide screenings to elucidate molecular mechanisms of the inflammation amplifier, a NFκB/STAT3-dependent machinery that potently drives recruitment of immune cells to promote inflammation. Using a public database of genome-wide association studies (GWAS), we recently reported the reverse-direction method by which our mass screening data were successfully linked to many human diseases. As an example, the epiregulin–epidermal growth factor receptor pathway was identified as a regulator of the inflammation amplifier, and associated with human diseases by GWAS. In fact, serum epiregulin levels were higher in patients with chronic inflammatory disorders. The reverse-direction method can be a useful tool to narrow mass data down to focus on human disease-related genes.</abstract><cop>Basel</cop><pub>Springer Basel</pub><pmid>23995916</pmid><doi>10.1007/s00005-013-0255-9</doi><tpages>5</tpages></addata></record> |
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| ispartof | Archivum Immunologiae et Therapiae Experimentalis, 2014-02, Vol.62 (1), p.41-45 |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Cell Movement Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Epiregulin Genome-Wide Association Study High-Throughput Screening Assays Humans Immune System Diseases - diagnosis Immune System Diseases - immunology Immunology Inflammation Mediators - metabolism Mass Screening - methods Mass Screening - trends NF-kappa B - metabolism Pharmacology/Toxicology Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Review Signal Transduction STAT3 Transcription Factor - metabolism Translational Medical Research |
| title | The Reverse-Direction Method Links Mass Experimental Data to Human Diseases |
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