Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D2
Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D2. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation reveal...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2013/10/01, Vol.61(10), pp.1024-1029 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | Kotoku, Naoyuki Mizushima, Kohei Tamura, Satoru Kobayashi, Motomasa |
| description | Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D2. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs). |
| doi_str_mv | 10.1248/cpb.c13-00375 |
| format | Article |
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Pharm. Bull.</addtitle><description>Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D2. 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| ispartof | Chemical and Pharmaceutical Bulletin, 2013/10/01, Vol.61(10), pp.1024-1029 |
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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | analogue synthesis anti-angiogenesis cortistatin A marine sponge vitamin D2 |
| title | Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D2 |
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