An ent-Kaurane Diterpenoid from Croton tonkinensis Induces Apoptosis by Regulating AMP-Activated Protein Kinase in SK-HEP1 Human Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality worldwide. Traditional chemotherapy for HCC is not widely accepted by clinical practitioners because of its toxic side effects. Thus, there is a need to identify chemotherapeutic drugs against HCC. AMP-activat...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2013/01/01, Vol.36(1), pp.158-164
Hauptverfasser:	Sul, Young Hoon, Lee, Myung Sun, Cha, Eun Young, Thuong, Phuong Thien, Khoi, Nguyen Minh, Song, In Sang
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Antineoplastic Agents - pharmacology Apoptosis - drug effects Carcinoma, Hepatocellular Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Croton Diterpenes, Kaurane - pharmacology ent-kaurane diterpenoid hepatocellular carcinoma Humans Plant Leaves
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