D3 HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)

The cellular adhesion molecule LFA-1 and its ICAM-1 ligand play an important role in promoting HIV-1 infectivity and transmission. These molecules are present on the envelope of HIV-1 virions and are integral components of the HIV virological synapse. However, cellular activation is required to conv...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2012-04, Vol.59, p.1
Hauptverfasser:	Hioe, C E, Tuen, M, Vasiliver-Shamis, G, Alvarez, Y, Prins, K C, Banarjee, S, Nadas, A, Cho, M W, Dustin, M L, Kachlany, S C
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell adhesion & migration HIV Human immunodeficiency virus Ligands Lymphocytes Molecules Toxins
Online-Zugang:	Volltext
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