Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b^sup 0,+^AT (Slc7a9) in mice

Cystinuria is an autosomal recessive disease caused by mutations in SLC3A1 (rBAT) and SLC7A9 (b0,+AT). Gene targeting of the catalytic subunit (Slc7a9) in mice leads to excessive excretion of cystine, lysine, arginine, and ornithine. Here, we studied this non-type I cystinuria mouse model using gene...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2013-12, Vol.305 (12), p.F1645
Hauptverfasser:	Di Giacopo, Andrea, Rubio-Aliaga, Isabel, Cantone, Alessandra, Artunc, Ferruh, Rexhepaj, Rexhep, Frey-Wagner, Isabelle, Font-Llitjós, Mariona, Gehring, Nicole, Stange, Gerti, Jaenecke, Isabel, Mohebbi, Nilufar, Closs, Ellen I, Palacín, Manuel, Nunes, Virginia, Daniel, Hannelore, Lang, Florian, Capasso, Giovambattista, Wagner, Carsten A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Gene expression Kidney diseases Membranes Mutation Peptides Rodents
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