PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1[alpha] suppression

Glioblastoma (GBM) is the most common brain cancer and is highly lethal in both adults and children. 2-methoxyestradiol (2ME2) is a microtubule inhibitor that potently inhibits HIF1[alpha], GBM angiogenesis and tumor growth in preclinical models. In patients, 2ME2 exhibits low toxicity and promising...

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Veröffentlicht in:	Journal of neuro-oncology 2014-01, Vol.116 (1), p.89
Hauptverfasser:	Muh, Carrie R, Joshi, Shweta, Singh, Alok R, Kesari, Santosh, Durden, Donald L, Makale, Milan T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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