Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the underlying mechanisms of this association have not been clarified. We aimed to elucidate the precise role of cholesterol in the pathophysiology of NASH. C57BL/6 mice were fed a control, high‐cholesterol (HC), m...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2014-01, Vol.59 (1), p.154-169
Hauptverfasser:	Tomita, Kengo, Teratani, Toshiaki, Suzuki, Takahiro, Shimizu, Motonori, Sato, Hirokazu, Narimatsu, Kazuyuki, Okada, Yoshikiyo, Kurihara, Chie, Irie, Rie, Yokoyama, Hirokazu, Shimamura, Katsuyoshi, Usui, Shingo, Ebinuma, Hirotoshi, Saito, Hidetsugu, Watanabe, Chikako, Komoto, Shunsuke, Kawaguchi, Atsushi, Nagao, Shigeaki, Sugiyama, Kazuo, Hokari, Ryota, Kanai, Takanori, Miura, Soichiro, Hibi, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholesterol Cholesterol - administration & dosage Cholesterol - metabolism Disease Models, Animal Down-Regulation Fatty Liver - complications Fatty Liver - metabolism Hepatic Stellate Cells - metabolism Hepatology Homeostasis Liver cirrhosis Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Macrophage Activation Male Membrane Proteins - metabolism Mice Mice, Inbred C57BL MicroRNAs - metabolism PPAR gamma - metabolism Proteins Receptors, LDL - metabolism RNA, Messenger - metabolism Rodents Signal Transduction Sterol Regulatory Element Binding Protein 2 - metabolism Toll-Like Receptor 4 - metabolism Transforming Growth Factor beta - metabolism Up-Regulation
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