Rat GnRH Neurons Exhibit Large Conductance Voltage- and Ca2+-Activated K+ (BK) Currents and Express BK Channel mRNAs

Gonadotropin-releasing hormone (GnRH) neurons form the final common pathway for the central regulation of reproduction. As in other neurons, the discharge pattern of action potentials is important for these neurons to function properly. Therefore it is important to elucidate the expression patterns...

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Veröffentlicht in:	Journal of Physiological Sciences 2008, Vol.58(1), pp.21-29
Hauptverfasser:	Hiraizumi, Yoshie, Nishimura, Ichiro, Ishii, Hirotaka, Tanaka, Nobuyuki, Takeshita, Toshiyuki, Sakuma, Yasuo, Kato, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Animals, Genetically Modified Cadmium - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology calcium-activated potassium channel Cells, Cultured charybdotoxin Charybdotoxin - pharmacology Delayed Rectifier Potassium Channels - physiology Female Gonadotropin-Releasing Hormone - genetics Gonadotropin-Releasing Hormone - physiology Green Fluorescent Proteins - genetics Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - physiology Large-Conductance Calcium-Activated Potassium Channel beta Subunits - physiology Male Nerve Tissue Proteins - physiology Neurons - cytology Neurons - physiology Nickel - pharmacology patch-clamp Patch-Clamp Techniques Potassium - metabolism potassium channel Potassium Channels, Calcium-Activated - physiology Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism RT-PCR Small-Conductance Calcium-Activated Potassium Channels - physiology
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