EFFECTS OF DI-ISONONYL PHTHALATE (DINP) ON PEROXISOMAL MARKERS IN THE MARMOSET-DINP IS NOT A PEROXISOME PROLIFERATOR

In the present study the systemic toxic potential of di-isononyl phthalate (DINP) was assessed in a 13-week study in marmosets. Particular attention was given to its potential for hepatic peroxisome proliferation. Three groups of four male and four female marmosets received DINP, by oral gavage admi...

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Veröffentlicht in:	Journal of toxicological sciences 1999/08/17, Vol.24(3), pp.237-244
Hauptverfasser:	HALL, Michael, MATTHEWS, Anne, WEBLEY, Lisa, HARLING, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers Callithrix Cell Fractionation Chemical and industrial products toxicology. Toxic occupational diseases Clofibrate - chemistry Clofibrate - toxicity Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 CYP4A Cytochrome P-450 Enzyme System - metabolism Diethylhexyl Phthalate - chemistry Diethylhexyl Phthalate - toxicity Female Kidney - drug effects Kidney - pathology Liver - drug effects Liver - enzymology Liver - pathology Male Medical sciences Membrane Proteins - drug effects Membrane Proteins - metabolism Microbodies - drug effects Microbodies - enzymology Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism Organ Size - drug effects Oxidoreductases - metabolism Peroxisome Peroxisome Proliferators - chemistry Peroxisome Proliferators - toxicity Phthalic Acids - chemistry Phthalic Acids - toxicity Salivary Glands - drug effects Salivary Glands - pathology Toxicity Tests Toxicology Various organic compounds Weight Gain - drug effects
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