28-DAY REPEATED ORAL TOXICITY STUDY OF A HYPOLIPIDEMIC AGENT, NK-104 IN RATS

NK-104, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, was administered orally to Wistar rats at a dose of 2, 10, 50 or 100 mg/kg for 28 days consecutively, and the toxicity of NK-104 and its recovery with 2 weeks cessation of drug treatment were examined. As major clinical signs, loose s...

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Veröffentlicht in:	Journal of toxicological sciences 1998/11/26, Vol.23(SupplementV), pp.701-711
Hauptverfasser:	AKIBA, Tomohide, SHIBUTA, Tetsuo, AMANO, Yukinori, OKUBO, Masato, ASANUMA, Akimune, KOGA, Teruji, TANAKA, Masahiro, TAKIMOTO, Masayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Body Weight - drug effects Cholinesterases - blood Diarrhea - chemically induced Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Eating - drug effects Emaciation - chemically induced Female Gastric Mucosa - drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity Hypolipidemic Agents - administration & dosage Hypolipidemic Agents - toxicity Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Muscle, Skeletal - drug effects No-Observed-Adverse-Effect Level Pharmacology. Drug treatments Quinolines - administration & dosage Quinolines - toxicity Rat Rats Rats, Wistar Time Factors
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