SINGLE DOSE TOXICITY STUDIES OF MONTIRELIN HYDRATE(NS-3) IN MICE, RATS AND DOGS

The single dose toxicity studies of montirelin hydrate (NS-3), a new drug for the treatment of disturbance of consciousness, were conducted in Slc : ddY mice, Slt : SD rats, and beagle dogs of both sexes. The drug was administered intravenously (i.v.) to mice, rats and dogs, and intramuscularly (i.m...

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Veröffentlicht in:	Journal of toxicological sciences 1995/12/25, Vol.20(SupplementII), pp.153-163
Hauptverfasser:	KIKUMORI, Mikito, NISHIDA, Ikuo, NISHIMURA, Takayoshi, YASUHIRA, Kimio, NAKAI, Nobuko, NISHIGUCHI, Yasuyuki, IWAKURA, Keiko, NAGASAWA, Hisamitsu, SUMI, Nobuyoshi
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Animals Body Weight - drug effects Dog Dogs Drinking - drug effects Eating - drug effects Female Injections, Intramuscular Injections, Intravenous Lethal Dose 50 Locomotion - drug effects Male Mice Organ Size - drug effects Rats Rats, Sprague-Dawley Salivation - drug effects Thyrotropin-Releasing Hormone - administration & dosage Thyrotropin-Releasing Hormone - analogs & derivatives Thyrotropin-Releasing Hormone - toxicity Tremor - chemically induced
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