EFFECTS OF POSTNATAL LOW-LEVELS OF EXPOSURE TO STYRENE ON BEHAVIOR AND DEVELOPMENT IN RATS
Three groups of rats were exposed by inhalation to either clean air (control group) or styrene monomer at 25 and 50 ppm (styrene-exposed groups) for 7 h/day, 6 day/week, from 1 to 48 days of age. Compared to control group, Styrene-exposed groups showed significant delay in the following developmenta...
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| Veröffentlicht in: | Journal of toxicological sciences 1989/11/25, Vol.14(4), pp.279-286 |
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| container_title | Journal of toxicological sciences |
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| creator | SHIGETA, Sadayoshi MIYAKE, Kumiko AIKAWA, Hiroyuki MISAWA, Tetsuo |
| description | Three groups of rats were exposed by inhalation to either clean air (control group) or styrene monomer at 25 and 50 ppm (styrene-exposed groups) for 7 h/day, 6 day/week, from 1 to 48 days of age. Compared to control group, Styrene-exposed groups showed significant delay in the following developmental indices : body weight gain, appearance of pinna detachment and incisor eruption. With respect to open-field activity, the styrene groups indicated longer latency to enter the field, less number of squares crossed and fewer rearings than those of controls. In the avoidance behavior aspect, the styrene groups attained less achievement level in avoidance rates than that of the control group. Dose-related trends were found between the two exposed groups in body weight increment, exploratory and avoidance behavior. Sex differences were seen on these factors also. These results suggest that at postnatal exposure of low-levels to styrene affects behavior and development in rats. |
| doi_str_mv | 10.2131/jts.14.279 |
| format | Article |
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Compared to control group, Styrene-exposed groups showed significant delay in the following developmental indices : body weight gain, appearance of pinna detachment and incisor eruption. With respect to open-field activity, the styrene groups indicated longer latency to enter the field, less number of squares crossed and fewer rearings than those of controls. In the avoidance behavior aspect, the styrene groups attained less achievement level in avoidance rates than that of the control group. Dose-related trends were found between the two exposed groups in body weight increment, exploratory and avoidance behavior. Sex differences were seen on these factors also. These results suggest that at postnatal exposure of low-levels to styrene affects behavior and development in rats.</description><identifier>ISSN: 0388-1350</identifier><identifier>EISSN: 1880-3989</identifier><identifier>DOI: 10.2131/jts.14.279</identifier><identifier>PMID: 2625709</identifier><identifier>CODEN: JTSCDR</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Toxicology</publisher><subject>Animals ; Animals, Newborn - physiology ; Avoidance Learning - drug effects ; Behavior, Animal - drug effects ; Biological and medical sciences ; Body Weight - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; development ; Exploratory Behavior - drug effects ; Female ; Growth - drug effects ; Male ; Medical sciences ; Rats ; Sex Factors ; Solvents ; Styrenes - toxicity ; Toxicology</subject><ispartof>The Journal of Toxicological Sciences, 1989/11/25, Vol.14(4), pp.279-286</ispartof><rights>The Japanese Society of Toxicology Headquarters</rights><rights>1990 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1989</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5179-1da5b208f710d0f9b6a8508ab5bebfe021033cb87d3b55d0ae6edc4b2b6fa4a83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6859681$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2625709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIGETA, Sadayoshi</creatorcontrib><creatorcontrib>MIYAKE, Kumiko</creatorcontrib><creatorcontrib>AIKAWA, Hiroyuki</creatorcontrib><creatorcontrib>MISAWA, Tetsuo</creatorcontrib><title>EFFECTS OF POSTNATAL LOW-LEVELS OF EXPOSURE TO STYRENE ON BEHAVIOR AND DEVELOPMENT IN RATS</title><title>Journal of toxicological sciences</title><addtitle>J Toxicol Sci</addtitle><description>Three groups of rats were exposed by inhalation to either clean air (control group) or styrene monomer at 25 and 50 ppm (styrene-exposed groups) for 7 h/day, 6 day/week, from 1 to 48 days of age. 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These results suggest that at postnatal exposure of low-levels to styrene affects behavior and development in rats.</description><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Avoidance Learning - drug effects</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Chemical and industrial products toxicology. 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Toxic occupational diseases</topic><topic>development</topic><topic>Exploratory Behavior - drug effects</topic><topic>Female</topic><topic>Growth - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Sex Factors</topic><topic>Solvents</topic><topic>Styrenes - toxicity</topic><topic>Toxicology</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIGETA, Sadayoshi</creatorcontrib><creatorcontrib>MIYAKE, Kumiko</creatorcontrib><creatorcontrib>AIKAWA, Hiroyuki</creatorcontrib><creatorcontrib>MISAWA, Tetsuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIGETA, Sadayoshi</au><au>MIYAKE, Kumiko</au><au>AIKAWA, Hiroyuki</au><au>MISAWA, Tetsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF POSTNATAL LOW-LEVELS OF EXPOSURE TO STYRENE ON BEHAVIOR AND DEVELOPMENT IN RATS</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>1989</date><risdate>1989</risdate><volume>14</volume><issue>4</issue><spage>279</spage><epage>286</epage><pages>279-286</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><coden>JTSCDR</coden><abstract>Three groups of rats were exposed by inhalation to either clean air (control group) or styrene monomer at 25 and 50 ppm (styrene-exposed groups) for 7 h/day, 6 day/week, from 1 to 48 days of age. 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| ispartof | The Journal of Toxicological Sciences, 1989/11/25, Vol.14(4), pp.279-286 |
| issn | 0388-1350 1880-3989 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Animals, Newborn - physiology Avoidance Learning - drug effects Behavior, Animal - drug effects Biological and medical sciences Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases development Exploratory Behavior - drug effects Female Growth - drug effects Male Medical sciences Rats Sex Factors Solvents Styrenes - toxicity Toxicology |
| title | EFFECTS OF POSTNATAL LOW-LEVELS OF EXPOSURE TO STYRENE ON BEHAVIOR AND DEVELOPMENT IN RATS |
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