STUDIES ON ANTIGENICITY, PHOTOTOXICITY AND OTHER SPECIFIC TOXICITIES OF HYDROCORTISONE 17-BUTYRATE 21-PROPIONATE (HBP)
The present experiments were undertaken to determine the antigenicity and other toxicities of HBP ; such as phototoxicity, photosensitivity, ulcerogenicity, androgenic-myotropic, estrogenic and progestational activities, and mutagenicity. No antibody formation and delayed type skin reaction of HBP w...
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| Veröffentlicht in: | Journal of toxicological sciences 1981/07/25, Vol.6(Supplement), pp.159-178 |
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| creator | OTOMO, Susumu SAZIKI, Ryuichi TSUCHIDA, Katsuharu KURACHI, Michio NAKAIKE, Shiro ARAI, Iwao TAKESHITA, Kimiyo MORI, Chizuko NAKANE, Sadao TARUMOTO, Yasuo OSHIMA, Takashi SASAJIMA, Michitada YASUI, Hajime OHZEKI, Masahiro |
| description | The present experiments were undertaken to determine the antigenicity and other toxicities of HBP ; such as phototoxicity, photosensitivity, ulcerogenicity, androgenic-myotropic, estrogenic and progestational activities, and mutagenicity. No antibody formation and delayed type skin reaction of HBP were seen in rabbits. Active systemic anaphylaxis was not observed in guinea pigs challenged by HBP. In the phototoxicity and photosensitivity test, 0.1% HBP ointment, 0.1% HBP cream and 10% HBP acetone solution did not show any skin reaction with or without irradiation of ultraviolet light. Repeated subcutaneous administrations of HBP irritated the gastric and intestinal mucosa dose dependently in rats as hydrocortisone 17-butyrate and betamethasone 17-valerate (BV). HBP had netiher androgenic-myotropic nor estrogenic activity, but antiestrogenic activity was observed. The progestational activity of HBP in immature rabbit pretreated with estrone was less potent than BV. In the mutagenicity test of HBP investigated by the reverse mutation according to the method by Ames, no significant increase in the number of revertants was observed in the presence or absence of S9 mixture. |
| doi_str_mv | 10.2131/jts.6.Supplement_159 |
| format | Article |
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No antibody formation and delayed type skin reaction of HBP were seen in rabbits. Active systemic anaphylaxis was not observed in guinea pigs challenged by HBP. In the phototoxicity and photosensitivity test, 0.1% HBP ointment, 0.1% HBP cream and 10% HBP acetone solution did not show any skin reaction with or without irradiation of ultraviolet light. Repeated subcutaneous administrations of HBP irritated the gastric and intestinal mucosa dose dependently in rats as hydrocortisone 17-butyrate and betamethasone 17-valerate (BV). HBP had netiher androgenic-myotropic nor estrogenic activity, but antiestrogenic activity was observed. The progestational activity of HBP in immature rabbit pretreated with estrone was less potent than BV. 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No antibody formation and delayed type skin reaction of HBP were seen in rabbits. Active systemic anaphylaxis was not observed in guinea pigs challenged by HBP. In the phototoxicity and photosensitivity test, 0.1% HBP ointment, 0.1% HBP cream and 10% HBP acetone solution did not show any skin reaction with or without irradiation of ultraviolet light. Repeated subcutaneous administrations of HBP irritated the gastric and intestinal mucosa dose dependently in rats as hydrocortisone 17-butyrate and betamethasone 17-valerate (BV). HBP had netiher androgenic-myotropic nor estrogenic activity, but antiestrogenic activity was observed. The progestational activity of HBP in immature rabbit pretreated with estrone was less potent than BV. In the mutagenicity test of HBP investigated by the reverse mutation according to the method by Ames, no significant increase in the number of revertants was observed in the presence or absence of S9 mixture.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - immunology</subject><subject>Anti-Inflammatory Agents - toxicity</subject><subject>Antibody Formation</subject><subject>Antigens - immunology</subject><subject>Betamethasone Valerate - toxicity</subject><subject>Digestive System - drug effects</subject><subject>Drug Hypersensitivity - etiology</subject><subject>Female</subject><subject>Genitalia, Male - drug effects</subject><subject>Guinea Pigs</subject><subject>Hydrocortisone - analogs & derivatives</subject><subject>Hydrocortisone - toxicity</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mutagenicity</subject><subject>Mutagens</subject><subject>Photosensitivity Disorders - chemically induced</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Skin - drug effects</subject><subject>Uterus - drug effects</subject><issn>0388-1350</issn><issn>1880-3989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd1q20AQhZfSkrpp36CFhd60ULk7Xu3fpSPL0ULQCmkN9dWysldthO24khzI21eNTWiZi-HwnZmBOQh9BDKdAYXv7dBP-bQ6HY-7sA-HwQFTr9AEpCQRVVK9RhNCpYyAMvIWvev7lpCZICy-QleCAlEUJuixsquFTitscjzPrb5Nc51ou_6Gi8zYsX48y5EtsLFZWuKqSBO91Am-sOfhJc7Wi9IkprS6MnmKQUQ3K7su5zbFM4iK0hTa5H_Vl-ym-PoevWn8rg8fLv0arZapTbLoztzqZH4XtaDiIQJCY6YkjwWHQKT3inq64Y2UoW6aWmyF8DWVirEGYgrbugbgQrCaMEmo4vQafT7vPXYPv0-hH1z7cOoO40kHMZdixs6uTxfXqd6HrTt293vfPbnLl0ZenXnbD_5neOG-G-43u-DGJEAJ7rj7J43_xBjNi3vzy3cuHOgfuKWBAg</recordid><startdate>1981</startdate><enddate>1981</enddate><creator>OTOMO, Susumu</creator><creator>SAZIKI, Ryuichi</creator><creator>TSUCHIDA, Katsuharu</creator><creator>KURACHI, Michio</creator><creator>NAKAIKE, Shiro</creator><creator>ARAI, Iwao</creator><creator>TAKESHITA, Kimiyo</creator><creator>MORI, Chizuko</creator><creator>NAKANE, Sadao</creator><creator>TARUMOTO, Yasuo</creator><creator>OSHIMA, Takashi</creator><creator>SASAJIMA, Michitada</creator><creator>YASUI, Hajime</creator><creator>OHZEKI, Masahiro</creator><general>The Japanese Society of Toxicology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>1981</creationdate><title>STUDIES ON ANTIGENICITY, PHOTOTOXICITY AND OTHER SPECIFIC TOXICITIES OF HYDROCORTISONE 17-BUTYRATE 21-PROPIONATE (HBP)</title><author>OTOMO, Susumu ; SAZIKI, Ryuichi ; TSUCHIDA, Katsuharu ; KURACHI, Michio ; NAKAIKE, Shiro ; ARAI, Iwao ; TAKESHITA, Kimiyo ; MORI, Chizuko ; NAKANE, Sadao ; TARUMOTO, Yasuo ; OSHIMA, Takashi ; SASAJIMA, Michitada ; YASUI, Hajime ; OHZEKI, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j194t-103459864761e08aa93a3c6f88ebffb7d77ab38955f1431dbb116775b05803963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1981</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - immunology</topic><topic>Anti-Inflammatory Agents - toxicity</topic><topic>Antibody Formation</topic><topic>Antigens - immunology</topic><topic>Betamethasone Valerate - toxicity</topic><topic>Digestive System - drug effects</topic><topic>Drug Hypersensitivity - etiology</topic><topic>Female</topic><topic>Genitalia, Male - drug effects</topic><topic>Guinea Pigs</topic><topic>Hydrocortisone - analogs & derivatives</topic><topic>Hydrocortisone - toxicity</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mutagenicity</topic><topic>Mutagens</topic><topic>Photosensitivity Disorders - chemically induced</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Skin - drug effects</topic><topic>Uterus - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>OTOMO, Susumu</creatorcontrib><creatorcontrib>SAZIKI, Ryuichi</creatorcontrib><creatorcontrib>TSUCHIDA, Katsuharu</creatorcontrib><creatorcontrib>KURACHI, Michio</creatorcontrib><creatorcontrib>NAKAIKE, Shiro</creatorcontrib><creatorcontrib>ARAI, Iwao</creatorcontrib><creatorcontrib>TAKESHITA, Kimiyo</creatorcontrib><creatorcontrib>MORI, Chizuko</creatorcontrib><creatorcontrib>NAKANE, Sadao</creatorcontrib><creatorcontrib>TARUMOTO, Yasuo</creatorcontrib><creatorcontrib>OSHIMA, Takashi</creatorcontrib><creatorcontrib>SASAJIMA, Michitada</creatorcontrib><creatorcontrib>YASUI, Hajime</creatorcontrib><creatorcontrib>OHZEKI, Masahiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OTOMO, Susumu</au><au>SAZIKI, Ryuichi</au><au>TSUCHIDA, Katsuharu</au><au>KURACHI, Michio</au><au>NAKAIKE, Shiro</au><au>ARAI, Iwao</au><au>TAKESHITA, Kimiyo</au><au>MORI, Chizuko</au><au>NAKANE, Sadao</au><au>TARUMOTO, Yasuo</au><au>OSHIMA, Takashi</au><au>SASAJIMA, Michitada</au><au>YASUI, Hajime</au><au>OHZEKI, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STUDIES ON ANTIGENICITY, PHOTOTOXICITY AND OTHER SPECIFIC TOXICITIES OF HYDROCORTISONE 17-BUTYRATE 21-PROPIONATE (HBP)</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>1981</date><risdate>1981</risdate><volume>6</volume><issue>Supplement</issue><spage>159</spage><epage>178</epage><pages>159-178</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><abstract>The present experiments were undertaken to determine the antigenicity and other toxicities of HBP ; such as phototoxicity, photosensitivity, ulcerogenicity, androgenic-myotropic, estrogenic and progestational activities, and mutagenicity. No antibody formation and delayed type skin reaction of HBP were seen in rabbits. Active systemic anaphylaxis was not observed in guinea pigs challenged by HBP. In the phototoxicity and photosensitivity test, 0.1% HBP ointment, 0.1% HBP cream and 10% HBP acetone solution did not show any skin reaction with or without irradiation of ultraviolet light. Repeated subcutaneous administrations of HBP irritated the gastric and intestinal mucosa dose dependently in rats as hydrocortisone 17-butyrate and betamethasone 17-valerate (BV). HBP had netiher androgenic-myotropic nor estrogenic activity, but antiestrogenic activity was observed. The progestational activity of HBP in immature rabbit pretreated with estrone was less potent than BV. In the mutagenicity test of HBP investigated by the reverse mutation according to the method by Ames, no significant increase in the number of revertants was observed in the presence or absence of S9 mixture.</abstract><cop>Japan</cop><pub>The Japanese Society of Toxicology</pub><pmid>7310931</pmid><doi>10.2131/jts.6.Supplement_159</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0388-1350 |
| ispartof | The Journal of Toxicological Sciences, 1981/07/25, Vol.6(Supplement), pp.159-178 |
| issn | 0388-1350 1880-3989 |
| language | eng ; jpn |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Administration, Topical Animals Anti-Inflammatory Agents - immunology Anti-Inflammatory Agents - toxicity Antibody Formation Antigens - immunology Betamethasone Valerate - toxicity Digestive System - drug effects Drug Hypersensitivity - etiology Female Genitalia, Male - drug effects Guinea Pigs Hydrocortisone - analogs & derivatives Hydrocortisone - toxicity Male Mice Mice, Inbred ICR Mutagenicity Mutagens Photosensitivity Disorders - chemically induced Rabbits Rats Rats, Inbred Strains Skin - drug effects Uterus - drug effects |
| title | STUDIES ON ANTIGENICITY, PHOTOTOXICITY AND OTHER SPECIFIC TOXICITIES OF HYDROCORTISONE 17-BUTYRATE 21-PROPIONATE (HBP) |
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