Quantitative Analyses of Lymphoid Tissue in the Spleen, Lymph Nodes and Peyer's Patches in Cynomolgus Monkeys
To clarify the morphological characteristics of the cynomolgus monkey immune system, we analyzed quantitative data on their lymphoid organs. Spleens, major lymph nodes and Peyer's patches were sampled from cynomolgus monkeys, and the lymphoid follicle and germinal center areas and percentages o...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2011, Vol.73(11), pp.1459-1464 |
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| creator | MORIYAMA, Akiko FUJISHIMA, Junko FURUKAWA, Tomohiro YOSHIKAWA, Tsuyoshi KODAMA, Rinya SASAKI, Yuji NAGAOKA, Takaharu KAMIMURA, Yasuhiro MAEDA, Hiroshi HIRAI, Takuya YAMAGUCHI, Ryoji |
| description | To clarify the morphological characteristics of the cynomolgus monkey immune system, we analyzed quantitative data on their lymphoid organs. Spleens, major lymph nodes and Peyer's patches were sampled from cynomolgus monkeys, and the lymphoid follicle and germinal center areas and percentages of CD3- and CD20-positive areas were calculated. All the organs analyzed showed large interindividual variations in the sizes of lymphoid follicles and germinal centers. Lymphoid follicle in the spleen, submandibular lymph nodes and Peyer's patches showed no marked difference in size. Germinal center size in the mesenteric lymph nodes and Peyer's patches were significantly smaller than those in the spleen. Areas containing T cells were largest in the lymph nodes, while those containing B cells were largest in the spleen and Peyer's patches. The mean size of the splenic lymphoid follicle in cynomolgus monkeys is larger than that in rats and similar to that in humans. Based on the large individual variation and the characteristics of lymphoid organs, it is important to use cynomolgus monkeys in standard toxicity studies. Taking advantage of the characteristics of each species enables reliable evaluation of the immunologic system in standard toxicity studies. |
| doi_str_mv | 10.1292/jvms.11-0207 |
| format | Article |
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Spleens, major lymph nodes and Peyer's patches were sampled from cynomolgus monkeys, and the lymphoid follicle and germinal center areas and percentages of CD3- and CD20-positive areas were calculated. All the organs analyzed showed large interindividual variations in the sizes of lymphoid follicles and germinal centers. Lymphoid follicle in the spleen, submandibular lymph nodes and Peyer's patches showed no marked difference in size. Germinal center size in the mesenteric lymph nodes and Peyer's patches were significantly smaller than those in the spleen. Areas containing T cells were largest in the lymph nodes, while those containing B cells were largest in the spleen and Peyer's patches. The mean size of the splenic lymphoid follicle in cynomolgus monkeys is larger than that in rats and similar to that in humans. Based on the large individual variation and the characteristics of lymphoid organs, it is important to use cynomolgus monkeys in standard toxicity studies. Taking advantage of the characteristics of each species enables reliable evaluation of the immunologic system in standard toxicity studies.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.11-0207</identifier><identifier>PMID: 21757856</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; Antigens, CD20 - metabolism ; B-Lymphocytes - metabolism ; CD3 Complex - metabolism ; cynomolgus monkey ; Female ; immunotoxicity ; lymph node ; Lymph Nodes - anatomy & histology ; Lymph Nodes - metabolism ; Lymphoid Tissue - anatomy & histology ; Lymphoid Tissue - metabolism ; Macaca fascicularis - anatomy & histology ; Macaca fascicularis - immunology ; Macaca fascicularis - metabolism ; Male ; Organ Size ; Peyer's patches ; Peyer's Patches - anatomy & histology ; Peyer's Patches - metabolism ; spleen ; Spleen - anatomy & histology ; Spleen - metabolism ; T-Lymphocytes - metabolism</subject><ispartof>Journal of Veterinary Medical Science, 2011, Vol.73(11), pp.1459-1464</ispartof><rights>2011 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-d15408a068cf9963835641a92386b4700ef07d320aa61114804c68117c16c5ef3</citedby><cites>FETCH-LOGICAL-c440t-d15408a068cf9963835641a92386b4700ef07d320aa61114804c68117c16c5ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21757856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORIYAMA, Akiko</creatorcontrib><creatorcontrib>FUJISHIMA, Junko</creatorcontrib><creatorcontrib>FURUKAWA, Tomohiro</creatorcontrib><creatorcontrib>YOSHIKAWA, Tsuyoshi</creatorcontrib><creatorcontrib>KODAMA, Rinya</creatorcontrib><creatorcontrib>SASAKI, Yuji</creatorcontrib><creatorcontrib>NAGAOKA, Takaharu</creatorcontrib><creatorcontrib>KAMIMURA, Yasuhiro</creatorcontrib><creatorcontrib>MAEDA, Hiroshi</creatorcontrib><creatorcontrib>HIRAI, Takuya</creatorcontrib><creatorcontrib>YAMAGUCHI, Ryoji</creatorcontrib><title>Quantitative Analyses of Lymphoid Tissue in the Spleen, Lymph Nodes and Peyer's Patches in Cynomolgus Monkeys</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>To clarify the morphological characteristics of the cynomolgus monkey immune system, we analyzed quantitative data on their lymphoid organs. Spleens, major lymph nodes and Peyer's patches were sampled from cynomolgus monkeys, and the lymphoid follicle and germinal center areas and percentages of CD3- and CD20-positive areas were calculated. All the organs analyzed showed large interindividual variations in the sizes of lymphoid follicles and germinal centers. Lymphoid follicle in the spleen, submandibular lymph nodes and Peyer's patches showed no marked difference in size. Germinal center size in the mesenteric lymph nodes and Peyer's patches were significantly smaller than those in the spleen. Areas containing T cells were largest in the lymph nodes, while those containing B cells were largest in the spleen and Peyer's patches. The mean size of the splenic lymphoid follicle in cynomolgus monkeys is larger than that in rats and similar to that in humans. Based on the large individual variation and the characteristics of lymphoid organs, it is important to use cynomolgus monkeys in standard toxicity studies. Taking advantage of the characteristics of each species enables reliable evaluation of the immunologic system in standard toxicity studies.</description><subject>Animals</subject><subject>Antigens, CD20 - metabolism</subject><subject>B-Lymphocytes - metabolism</subject><subject>CD3 Complex - metabolism</subject><subject>cynomolgus monkey</subject><subject>Female</subject><subject>immunotoxicity</subject><subject>lymph node</subject><subject>Lymph Nodes - anatomy & histology</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymphoid Tissue - anatomy & histology</subject><subject>Lymphoid Tissue - metabolism</subject><subject>Macaca fascicularis - anatomy & histology</subject><subject>Macaca fascicularis - immunology</subject><subject>Macaca fascicularis - metabolism</subject><subject>Male</subject><subject>Organ Size</subject><subject>Peyer's patches</subject><subject>Peyer's Patches - anatomy & histology</subject><subject>Peyer's Patches - metabolism</subject><subject>spleen</subject><subject>Spleen - anatomy & histology</subject><subject>Spleen - metabolism</subject><subject>T-Lymphocytes - metabolism</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFu1DAQQC0EotvCjTOyxIFLUzy2YzvHagUFaYEiytlynUk3SxJvbadS_p5EKXvxSJ6nJ80j5B2wK-AV_3R46tMVQME40y_IBoTUhZaiekk2rAJVaF6yM3Ke0oExDlJVr8kZB11qU6oN6X-Nbshtdrl9Qno9uG5KmGho6G7qj_vQ1vSuTWlE2g4075H-PnaIw-W6pj9CPdNuqOktThg_Jnrrst_PfzO-nYbQh-5hTPR7GP7ilN6QV43rEr59nhfkz5fPd9uvxe7nzbft9a7wUrJc1FBKZhxTxjdVpYQRpZLgKi6MupeaMWyYrgVnzikAkIZJrwyA9qB8iY24IB9W7zGGxxFTtocwxvm4ZOcCRnNumJmpy5XyMaQUsbHH2PYuThaYXdrapa0FsEvbGX__LB3ve6xP8P-YM7BdgUPK7gFPgIu59R2uNi0W4fou2tPW7120OIh_qwaL-g</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>MORIYAMA, Akiko</creator><creator>FUJISHIMA, Junko</creator><creator>FURUKAWA, Tomohiro</creator><creator>YOSHIKAWA, Tsuyoshi</creator><creator>KODAMA, Rinya</creator><creator>SASAKI, Yuji</creator><creator>NAGAOKA, Takaharu</creator><creator>KAMIMURA, Yasuhiro</creator><creator>MAEDA, Hiroshi</creator><creator>HIRAI, Takuya</creator><creator>YAMAGUCHI, Ryoji</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20111101</creationdate><title>Quantitative Analyses of Lymphoid Tissue in the Spleen, Lymph Nodes and Peyer's Patches in Cynomolgus Monkeys</title><author>MORIYAMA, Akiko ; FUJISHIMA, Junko ; FURUKAWA, Tomohiro ; YOSHIKAWA, Tsuyoshi ; KODAMA, Rinya ; SASAKI, Yuji ; NAGAOKA, Takaharu ; KAMIMURA, Yasuhiro ; MAEDA, Hiroshi ; HIRAI, Takuya ; YAMAGUCHI, Ryoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-d15408a068cf9963835641a92386b4700ef07d320aa61114804c68117c16c5ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antigens, CD20 - metabolism</topic><topic>B-Lymphocytes - metabolism</topic><topic>CD3 Complex - metabolism</topic><topic>cynomolgus monkey</topic><topic>Female</topic><topic>immunotoxicity</topic><topic>lymph node</topic><topic>Lymph Nodes - anatomy & histology</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymphoid Tissue - anatomy & histology</topic><topic>Lymphoid Tissue - metabolism</topic><topic>Macaca fascicularis - anatomy & histology</topic><topic>Macaca fascicularis - immunology</topic><topic>Macaca fascicularis - metabolism</topic><topic>Male</topic><topic>Organ Size</topic><topic>Peyer's patches</topic><topic>Peyer's Patches - anatomy & histology</topic><topic>Peyer's Patches - metabolism</topic><topic>spleen</topic><topic>Spleen - anatomy & histology</topic><topic>Spleen - metabolism</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MORIYAMA, Akiko</creatorcontrib><creatorcontrib>FUJISHIMA, Junko</creatorcontrib><creatorcontrib>FURUKAWA, Tomohiro</creatorcontrib><creatorcontrib>YOSHIKAWA, Tsuyoshi</creatorcontrib><creatorcontrib>KODAMA, Rinya</creatorcontrib><creatorcontrib>SASAKI, Yuji</creatorcontrib><creatorcontrib>NAGAOKA, Takaharu</creatorcontrib><creatorcontrib>KAMIMURA, Yasuhiro</creatorcontrib><creatorcontrib>MAEDA, Hiroshi</creatorcontrib><creatorcontrib>HIRAI, Takuya</creatorcontrib><creatorcontrib>YAMAGUCHI, Ryoji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORIYAMA, Akiko</au><au>FUJISHIMA, Junko</au><au>FURUKAWA, Tomohiro</au><au>YOSHIKAWA, Tsuyoshi</au><au>KODAMA, Rinya</au><au>SASAKI, Yuji</au><au>NAGAOKA, Takaharu</au><au>KAMIMURA, Yasuhiro</au><au>MAEDA, Hiroshi</au><au>HIRAI, Takuya</au><au>YAMAGUCHI, Ryoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Analyses of Lymphoid Tissue in the Spleen, Lymph Nodes and Peyer's Patches in Cynomolgus Monkeys</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>73</volume><issue>11</issue><spage>1459</spage><epage>1464</epage><pages>1459-1464</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>To clarify the morphological characteristics of the cynomolgus monkey immune system, we analyzed quantitative data on their lymphoid organs. Spleens, major lymph nodes and Peyer's patches were sampled from cynomolgus monkeys, and the lymphoid follicle and germinal center areas and percentages of CD3- and CD20-positive areas were calculated. All the organs analyzed showed large interindividual variations in the sizes of lymphoid follicles and germinal centers. Lymphoid follicle in the spleen, submandibular lymph nodes and Peyer's patches showed no marked difference in size. Germinal center size in the mesenteric lymph nodes and Peyer's patches were significantly smaller than those in the spleen. Areas containing T cells were largest in the lymph nodes, while those containing B cells were largest in the spleen and Peyer's patches. The mean size of the splenic lymphoid follicle in cynomolgus monkeys is larger than that in rats and similar to that in humans. Based on the large individual variation and the characteristics of lymphoid organs, it is important to use cynomolgus monkeys in standard toxicity studies. Taking advantage of the characteristics of each species enables reliable evaluation of the immunologic system in standard toxicity studies.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>21757856</pmid><doi>10.1292/jvms.11-0207</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigens, CD20 - metabolism B-Lymphocytes - metabolism CD3 Complex - metabolism cynomolgus monkey Female immunotoxicity lymph node Lymph Nodes - anatomy & histology Lymph Nodes - metabolism Lymphoid Tissue - anatomy & histology Lymphoid Tissue - metabolism Macaca fascicularis - anatomy & histology Macaca fascicularis - immunology Macaca fascicularis - metabolism Male Organ Size Peyer's patches Peyer's Patches - anatomy & histology Peyer's Patches - metabolism spleen Spleen - anatomy & histology Spleen - metabolism T-Lymphocytes - metabolism |
| title | Quantitative Analyses of Lymphoid Tissue in the Spleen, Lymph Nodes and Peyer's Patches in Cynomolgus Monkeys |
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