Anaphylactoid response to optison(R) and its effects on pulmonary function in two dogs
Two of 26 anesthetized dogs given the cardiac echo-enhancing agent Optison(R) showed anaphylactoid responses (AR) related to the human albumin component of this agent. The episodes of AR were self-limited, and could be reproduced by human albumin injec-tion alone. Gas exchange was maintained by mech...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2004, Vol.66(11), pp.1429-1432 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | Yamaya, Y. (University of California, San Diego (USA)) Niizeki, K Kim, J Entin, P Wagner, H Wagner, P.D |
| description | Two of 26 anesthetized dogs given the cardiac echo-enhancing agent Optison(R) showed anaphylactoid responses (AR) related to the human albumin component of this agent. The episodes of AR were self-limited, and could be reproduced by human albumin injec-tion alone. Gas exchange was maintained by mechanical ventilation and 5 cm H2O PEEP, and dispersion of ventilation remained normal during AR despite severe hypotension. We suggest that: (1) pre-screening by measuring blood pressure response to intravenous injection of small doses of Optison(R). and (2) availability of access to the airway in addition to emergency agents may be prudent preventive mea-sures when Optison(R) is used in animals to enhance echocardiographic imaging. |
| doi_str_mv | 10.1292/jvms.66.1429 |
| format | Article |
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We suggest that: (1) pre-screening by measuring blood pressure response to intravenous injection of small doses of Optison(R). and (2) availability of access to the airway in addition to emergency agents may be prudent preventive mea-sures when Optison(R) is used in animals to enhance echocardiographic imaging.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.66.1429</identifier><identifier>PMID: 15585961</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>ALBUMINS ; Albumins - adverse effects ; ANAPHYLACTIC REACTIONS ; Anaphylaxis - chemically induced ; Anaphylaxis - physiopathology ; Anaphylaxis - veterinary ; Animals ; BLOOD PRESSURE ; Contrast Media - adverse effects ; Dog Diseases - chemically induced ; Dog Diseases - physiopathology ; DOGS ; DRUGS ; Fluorocarbons - adverse effects ; GAS EXCHANGE ; Hemodynamics - drug effects ; human albumin ; hypotension ; Male ; Pulmonary Gas Exchange - drug effects ; Vascular Resistance - drug effects</subject><ispartof>Journal of Veterinary Medical Science, 2004, Vol.66(11), pp.1429-1432</ispartof><rights>2004 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-cce14aa9fd4778a4a5fcfa76fb50d75940ee2f4c818a692b0f0a11673cde5e73</citedby><cites>FETCH-LOGICAL-c653t-cce14aa9fd4778a4a5fcfa76fb50d75940ee2f4c818a692b0f0a11673cde5e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15585961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaya, Y. 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| subjects | ALBUMINS Albumins - adverse effects ANAPHYLACTIC REACTIONS Anaphylaxis - chemically induced Anaphylaxis - physiopathology Anaphylaxis - veterinary Animals BLOOD PRESSURE Contrast Media - adverse effects Dog Diseases - chemically induced Dog Diseases - physiopathology DOGS DRUGS Fluorocarbons - adverse effects GAS EXCHANGE Hemodynamics - drug effects human albumin hypotension Male Pulmonary Gas Exchange - drug effects Vascular Resistance - drug effects |
| title | Anaphylactoid response to optison(R) and its effects on pulmonary function in two dogs |
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