Preclinical SPECT/CT Imaging of [Alpha]lv[Beta]6 Integrins for Molecular Stratification of Idiopathic Pulmonary Fibrosis

Transforming growth factor β activation by the αvβ6 integrin is central to the pathogenesis of idiopathic pulmonary fibrosis. Expression of the αvβ6 integrin is increased in fibrotic lung tissue and is a promising therapeutic target for treatment of the disease. Currently, measurement of αvβ6 integr...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2013-12, Vol.54 (12), p.2146
Hauptverfasser:	John, Alison E, Luckett, Jeni C, Tatler, Amanda L, Awais, Ramla O, Desai, Ami, Habgood, Anthony, Ludbrook, Steve, Blanchard, Andy D, Perkins, Alan C, Jenkins, R Gisli, Marshall, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Cystic fibrosis Lungs Pathogenesis Peptides Tomography
Online-Zugang:	Volltext
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