On the Cellular Uptake and Membrane Effect of the Multifunctional Peptide, TatLK15

Recently, the multifunctional peptide TatLK15 resulting from the fusion of the cell penetrating peptide Tat and the amphipathic peptide LK15 was shown to be efficient at mediating siRNA and shRNA delivery in leukemia cells to silence the bcr-abl oncoprotein. The present study focused on TatLK15 pept...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2014-01, Vol.103 (1), p.293-304
Hauptverfasser:	Alkotaji, Myasar, Pluen, Alain, Zindy, Egor, Hamrang, Zahra, Aojula, Harmesh
Format:	Artikel
Sprache:	eng
Schlagworte:	cell Cell Line, Tumor Cell Membrane - metabolism cell penetrating peptide circular dichroism diffusion Endocytosis - physiology fluorescence spectroscopy Gene Products, tat - metabolism Glycine - metabolism HT29 Cells Humans image analysis L-Lactate Dehydrogenase - metabolism Membrane Potentials - physiology membrane translocation peptide delivery Peptide Fragments - metabolism Peptides - metabolism Protein Structure, Secondary Tat toxicity
Online-Zugang:	Volltext
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