A Case of Pancreatic Nesidioblastosis with Aberrant Islet Cell Proliferation in a Beagle

A Case of Pancreatic Nesidioblastosis with Aberrant Islet Cell Proliferation in a Beagle

A 20-month-old female beagle showed a pancreatic nesidioblastosis with a curious proliferation of islet hormone-positive cells. These cells were characterized by a tubular or columnar pattern, occasionally with a rosette-like structure. Immunohistochemistry revealed that they were positive to insuli...

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Veröffentlicht in:Journal of Toxicologic Pathology 2004, Vol.17(1), pp.55-58
Hauptverfasser: Ohira, Toko, Ishizaki, Mayumi, Yamakawa, Seiki, Iwata, Hijiri, Imai, Kiyoshi, Enomoto, Makoto
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dog
insulin-positive
nesidioblastosis
pancreas
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container_issue 1
container_start_page 55
container_title Journal of Toxicologic Pathology
container_volume 17
creator Ohira, Toko
Ishizaki, Mayumi
Yamakawa, Seiki
Iwata, Hijiri
Imai, Kiyoshi
Enomoto, Makoto
description A 20-month-old female beagle showed a pancreatic nesidioblastosis with a curious proliferation of islet hormone-positive cells. These cells were characterized by a tubular or columnar pattern, occasionally with a rosette-like structure. Immunohistochemistry revealed that they were positive to insulin and chromogranin A and weakly-positive to glucagon and somatostatin in the cytoplasm, but negative for cytokeratin. PCNA- positive cells were also scattered among these proliferating cells. The present case appears to be a specific type of nesidioblastosis accompanied by a proliferation of previously unidentified islet-cells in a beagle.
doi_str_mv 10.1293/tox.17.55
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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese
subjects dog
insulin-positive
nesidioblastosis
pancreas
title A Case of Pancreatic Nesidioblastosis with Aberrant Islet Cell Proliferation in a Beagle
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