Effects of Salt Loading on Glomeruli in the Remnant Kidney Model
The purpose of the present study was to determine whether or not salt excess might increase systemic blood pressure, proteinuria, and progress glomerulosclerosis based on morphometric image analysis in the subtotally nephrectomized rats. Experiments were performed on twelve 6-week-old male Wistar ra...
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| Veröffentlicht in: | Journal of Toxicologic Pathology 2000, Vol.13(3), pp.159-163 |
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| container_title | Journal of Toxicologic Pathology |
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| creator | Sugimoto, Jiro Umeda, Asami Kusakabe, Manami Wazaki, Masahiko Okada, Miyoko Mutai, Mamoru |
| description | The purpose of the present study was to determine whether or not salt excess might increase systemic blood pressure, proteinuria, and progress glomerulosclerosis based on morphometric image analysis in the subtotally nephrectomized rats. Experiments were performed on twelve 6-week-old male Wistar rats weighing 200-250 g. Eight rats received 5/6 nephrectomy and after surgery, these rats were divided into the following 2 groups consisting of 4 rats each: Sham-operation group was given standard water without salt to drink and salt treatment group was given 1% NaCl solution to drink for two weeks. In this remnant kidney model, salt loading was slightly effective in elevating blood pressure and induced significant increases in urinary protein excretion and urinary volume and enhanced glomerular sclerosis. The present results suggest that in the early stage of rat remnant kidney model, salt loading accelerates glomerular alterations with renal dysfunction. |
| doi_str_mv | 10.1293/tox.13.159 |
| format | Article |
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The present results suggest that in the early stage of rat remnant kidney model, salt loading accelerates glomerular alterations with renal dysfunction.</description><subject>Glomerulosclerosis</subject><subject>Kidney</subject><subject>Nephrectomy</subject><subject>Salt</subject><subject>Wistar rat</subject><issn>0914-9198</issn><issn>1881-915X</issn><issn>1347-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpFkM1KAzEUhYMoWKsbnyDgTmhNJpOZZKUibRUrgnbhLsTkTjtlJqmZFOzbG5lWF_cH7nfPgYPQJSVjmkl2E_33mLIx5fIIDagQdCQp_zhGAyJpnnYpTtFZ160JyUrC2QDdTaoKTOywr_C7biKee21rt8Te4VnjWwjbpsa1w3EF-A1ap13Ez7V1sMMv3kJzjk4q3XRwsZ9DtJhOFg-Po_nr7Onhfj4yOedylHOw-pMaEIYZSaisrDa5sGWpjRWc07JgJBOcgAQwBTOcZ8wUZZFOkgMboqtedhP81xa6qNZ-G1xyVDQvyjzLhOSJuu4pE3zXBajUJtStDjtFifoNSKWAFGUqBZTgaQ-3YGujG--a2sG_rrUs0RutMkKIIoQywtJIlb5TK1iRCyLKJHTbC627qJfw56lDrE0DB0-2b-n5cDErHRQ49gPwLYRL</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Sugimoto, Jiro</creator><creator>Umeda, Asami</creator><creator>Kusakabe, Manami</creator><creator>Wazaki, Masahiko</creator><creator>Okada, Miyoko</creator><creator>Mutai, Mamoru</creator><general>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</general><general>The Japanese Society of Toxicologic Pathology</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2000</creationdate><title>Effects of Salt Loading on Glomeruli in the Remnant Kidney Model</title><author>Sugimoto, Jiro ; Umeda, Asami ; Kusakabe, Manami ; Wazaki, Masahiko ; Okada, Miyoko ; Mutai, Mamoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4559-45edab1ce8c3c9019fdac48d77acd855176302850e9eec63c5523c67655195e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Glomerulosclerosis</topic><topic>Kidney</topic><topic>Nephrectomy</topic><topic>Salt</topic><topic>Wistar rat</topic><toplevel>online_resources</toplevel><creatorcontrib>Sugimoto, Jiro</creatorcontrib><creatorcontrib>Umeda, Asami</creatorcontrib><creatorcontrib>Kusakabe, Manami</creatorcontrib><creatorcontrib>Wazaki, Masahiko</creatorcontrib><creatorcontrib>Okada, Miyoko</creatorcontrib><creatorcontrib>Mutai, Mamoru</creatorcontrib><creatorcontrib>Mitsubishi-Tokyo Pharmaceuticals</creatorcontrib><creatorcontrib>Incorporation</creatorcontrib><creatorcontrib>Yokohama Research Center</creatorcontrib><creatorcontrib>Pharmacokinetics and Toxicology Laboratory</creatorcontrib><creatorcontrib>Pharmaceuticals Research Laboratory I</creatorcontrib><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of Toxicologic Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugimoto, Jiro</au><au>Umeda, Asami</au><au>Kusakabe, Manami</au><au>Wazaki, Masahiko</au><au>Okada, Miyoko</au><au>Mutai, Mamoru</au><aucorp>Mitsubishi-Tokyo Pharmaceuticals</aucorp><aucorp>Incorporation</aucorp><aucorp>Yokohama Research Center</aucorp><aucorp>Pharmacokinetics and Toxicology Laboratory</aucorp><aucorp>Pharmaceuticals Research Laboratory I</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Salt Loading on Glomeruli in the Remnant Kidney Model</atitle><jtitle>Journal of Toxicologic Pathology</jtitle><addtitle>J Toxicol Pathol</addtitle><date>2000</date><risdate>2000</risdate><volume>13</volume><issue>3</issue><spage>159</spage><epage>163</epage><pages>159-163</pages><issn>0914-9198</issn><eissn>1881-915X</eissn><eissn>1347-7404</eissn><abstract>The purpose of the present study was to determine whether or not salt excess might increase systemic blood pressure, proteinuria, and progress glomerulosclerosis based on morphometric image analysis in the subtotally nephrectomized rats. 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| identifier | ISSN: 0914-9198 |
| ispartof | Journal of Toxicologic Pathology, 2000, Vol.13(3), pp.159-163 |
| issn | 0914-9198 1881-915X 1347-7404 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Glomerulosclerosis Kidney Nephrectomy Salt Wistar rat |
| title | Effects of Salt Loading on Glomeruli in the Remnant Kidney Model |
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