PROTECTIVE EFFECTS OF BUTYLATED HYDROXYANISOLE AGAINST BLEOMYCIN-INDUCED DIFFUSE ALVEOLAR DAMAGE IN HAMSTERS
The effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), on bleomycin-induced diffuse alveolar damage (DAD) were investigated in male Syrian golden hamsters. Six-week-old animals were treated with a single intratracheal administration of bleomycin (BLM; 5mg/5ml/kg) or an equ...
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| Veröffentlicht in: | Journal of Toxicologic Pathology 1995/03/31, Vol.8(1), pp.7-14 |
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| creator | Enami, Tomonori Nishikawa, Akiyoshi Furukawa, Fumio Mitsui, Masayuki Yoshimura, Hiroyuki Takahashi, Michihito Fukushima, Shoji |
| description | The effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), on bleomycin-induced diffuse alveolar damage (DAD) were investigated in male Syrian golden hamsters. Six-week-old animals were treated with a single intratracheal administration of bleomycin (BLM; 5mg/5ml/kg) or an equivalent volume of saline. Starting 1 day after the treatment, animals were given 1% BHA or 1% BHT in the diet or basal diet alone for 31 days. The survival rate of the BLM/BHA group (55%) was significantly higher than that of the BLM alone (15%) or BLM/BHT (15%) groups (p |
| doi_str_mv | 10.1293/tox.8.7 |
| format | Article |
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Six-week-old animals were treated with a single intratracheal administration of bleomycin (BLM; 5mg/5ml/kg) or an equivalent volume of saline. Starting 1 day after the treatment, animals were given 1% BHA or 1% BHT in the diet or basal diet alone for 31 days. The survival rate of the BLM/BHA group (55%) was significantly higher than that of the BLM alone (15%) or BLM/BHT (15%) groups (p<0.01). Histopathologically, the lungs of hamsters in the BLM alone group, which were found dead 1 week after the treatment, showed severe pulmonary edema with hemorrhage. These were clearly attenuated by the BHA treatment, which in addition, somewhat accelerated fibrosing and regenerative changes. Moreover, surviving animals in the BLM/BHA group showed a tendency for reduction of emphysematous changes as compared to those receiving BLM alone and consequently to retain the normal alveolar architecture. On the other hand, the BHT administration did not exert any apparent inhibitory effects on early alveolar damage. Our results thus clearly indicate that BHA exerts a protective effect on BLM-induced DAD in hamsters although BHT did not inhibit the lung injury under the present experimental conditions. Possible mechanisms for the differences in influence between BHA and BHT on BLM-induced DAD are discussed.</description><identifier>ISSN: 0914-9198</identifier><identifier>EISSN: 1881-915X</identifier><identifier>EISSN: 1347-7404</identifier><identifier>DOI: 10.1293/tox.8.7</identifier><language>eng</language><publisher>Tokyo: JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</publisher><subject>BHA ; BHT ; Bleomycin ; Lung damage ; Protective effect</subject><ispartof>Journal of Toxicologic Pathology, 1995/03/31, Vol.8(1), pp.7-14</ispartof><rights>The Japanese Society of Toxicologic Pathology</rights><rights>Copyright Japan Science and Technology Agency 1995</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4247-ad292e0372c94e7cb0f1e5c4270386349c00225dd2da16350b2a8cfb4147e383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Enami, Tomonori</creatorcontrib><creatorcontrib>Nishikawa, Akiyoshi</creatorcontrib><creatorcontrib>Furukawa, Fumio</creatorcontrib><creatorcontrib>Mitsui, Masayuki</creatorcontrib><creatorcontrib>Yoshimura, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Michihito</creatorcontrib><creatorcontrib>Fukushima, Shoji</creatorcontrib><title>PROTECTIVE EFFECTS OF BUTYLATED HYDROXYANISOLE AGAINST BLEOMYCIN-INDUCED DIFFUSE ALVEOLAR DAMAGE IN HAMSTERS</title><title>Journal of Toxicologic Pathology</title><addtitle>J Toxicol Pathol</addtitle><description>The effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), on bleomycin-induced diffuse alveolar damage (DAD) were investigated in male Syrian golden hamsters. Six-week-old animals were treated with a single intratracheal administration of bleomycin (BLM; 5mg/5ml/kg) or an equivalent volume of saline. Starting 1 day after the treatment, animals were given 1% BHA or 1% BHT in the diet or basal diet alone for 31 days. The survival rate of the BLM/BHA group (55%) was significantly higher than that of the BLM alone (15%) or BLM/BHT (15%) groups (p<0.01). Histopathologically, the lungs of hamsters in the BLM alone group, which were found dead 1 week after the treatment, showed severe pulmonary edema with hemorrhage. These were clearly attenuated by the BHA treatment, which in addition, somewhat accelerated fibrosing and regenerative changes. Moreover, surviving animals in the BLM/BHA group showed a tendency for reduction of emphysematous changes as compared to those receiving BLM alone and consequently to retain the normal alveolar architecture. On the other hand, the BHT administration did not exert any apparent inhibitory effects on early alveolar damage. Our results thus clearly indicate that BHA exerts a protective effect on BLM-induced DAD in hamsters although BHT did not inhibit the lung injury under the present experimental conditions. Possible mechanisms for the differences in influence between BHA and BHT on BLM-induced DAD are discussed.</description><subject>BHA</subject><subject>BHT</subject><subject>Bleomycin</subject><subject>Lung damage</subject><subject>Protective effect</subject><issn>0914-9198</issn><issn>1881-915X</issn><issn>1347-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNo90F1PwjAUBuDGaCKi8S808cKrYb9GuytTtg6WjM1sg7CrZoyiEATcINF_bxHDRXNOcp7TNi8Ajxj1MPHoy2H33RM9fgU6WAjseNidXYMO8jCzvSduwV3brhEiHLm0AzZvWVoov4imCqowtF0O0xAOJkUZy0IFcFQGWTorZRLlaaygHMooyQs4iFU6Lv0ocaIkmPgWBlEYTnIr4qlKY5nBQI7lUMEogSM5zguV5ffgZlltWvPwX7ugCFXhj5w4HUa-jJ2aEcadakE8YhDlpPaY4fUcLbFx7YwjKvqUebX9PnEXC7KocJ-6aE4qUS_nDDNuqKBd8HS-dt_svo6mPej17ths7Ysasz5nxK57Vj2fVd3s2rYxS71vVp9V86Mx0qcktU1SC82tfD3LdXuo3s3FVc1hVW_MydlghbX47_DLpP6oGm229BeHrHOO</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Enami, Tomonori</creator><creator>Nishikawa, Akiyoshi</creator><creator>Furukawa, Fumio</creator><creator>Mitsui, Masayuki</creator><creator>Yoshimura, Hiroyuki</creator><creator>Takahashi, Michihito</creator><creator>Fukushima, Shoji</creator><general>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1995</creationdate><title>PROTECTIVE EFFECTS OF BUTYLATED HYDROXYANISOLE AGAINST BLEOMYCIN-INDUCED DIFFUSE ALVEOLAR DAMAGE IN HAMSTERS</title><author>Enami, Tomonori ; Nishikawa, Akiyoshi ; Furukawa, Fumio ; Mitsui, Masayuki ; Yoshimura, Hiroyuki ; Takahashi, Michihito ; Fukushima, Shoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4247-ad292e0372c94e7cb0f1e5c4270386349c00225dd2da16350b2a8cfb4147e383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>BHA</topic><topic>BHT</topic><topic>Bleomycin</topic><topic>Lung damage</topic><topic>Protective effect</topic><toplevel>online_resources</toplevel><creatorcontrib>Enami, Tomonori</creatorcontrib><creatorcontrib>Nishikawa, Akiyoshi</creatorcontrib><creatorcontrib>Furukawa, Fumio</creatorcontrib><creatorcontrib>Mitsui, Masayuki</creatorcontrib><creatorcontrib>Yoshimura, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Michihito</creatorcontrib><creatorcontrib>Fukushima, Shoji</creatorcontrib><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of Toxicologic Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enami, Tomonori</au><au>Nishikawa, Akiyoshi</au><au>Furukawa, Fumio</au><au>Mitsui, Masayuki</au><au>Yoshimura, Hiroyuki</au><au>Takahashi, Michihito</au><au>Fukushima, Shoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PROTECTIVE EFFECTS OF BUTYLATED HYDROXYANISOLE AGAINST BLEOMYCIN-INDUCED DIFFUSE ALVEOLAR DAMAGE IN HAMSTERS</atitle><jtitle>Journal of Toxicologic Pathology</jtitle><addtitle>J Toxicol Pathol</addtitle><date>1995</date><risdate>1995</risdate><volume>8</volume><issue>1</issue><spage>7</spage><epage>14</epage><pages>7-14</pages><issn>0914-9198</issn><eissn>1881-915X</eissn><eissn>1347-7404</eissn><abstract>The effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), on bleomycin-induced diffuse alveolar damage (DAD) were investigated in male Syrian golden hamsters. Six-week-old animals were treated with a single intratracheal administration of bleomycin (BLM; 5mg/5ml/kg) or an equivalent volume of saline. Starting 1 day after the treatment, animals were given 1% BHA or 1% BHT in the diet or basal diet alone for 31 days. The survival rate of the BLM/BHA group (55%) was significantly higher than that of the BLM alone (15%) or BLM/BHT (15%) groups (p<0.01). Histopathologically, the lungs of hamsters in the BLM alone group, which were found dead 1 week after the treatment, showed severe pulmonary edema with hemorrhage. These were clearly attenuated by the BHA treatment, which in addition, somewhat accelerated fibrosing and regenerative changes. Moreover, surviving animals in the BLM/BHA group showed a tendency for reduction of emphysematous changes as compared to those receiving BLM alone and consequently to retain the normal alveolar architecture. On the other hand, the BHT administration did not exert any apparent inhibitory effects on early alveolar damage. Our results thus clearly indicate that BHA exerts a protective effect on BLM-induced DAD in hamsters although BHT did not inhibit the lung injury under the present experimental conditions. Possible mechanisms for the differences in influence between BHA and BHT on BLM-induced DAD are discussed.</abstract><cop>Tokyo</cop><pub>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</pub><doi>10.1293/tox.8.7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-9198 |
| ispartof | Journal of Toxicologic Pathology, 1995/03/31, Vol.8(1), pp.7-14 |
| issn | 0914-9198 1881-915X 1347-7404 |
| language | eng |
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| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | BHA BHT Bleomycin Lung damage Protective effect |
| title | PROTECTIVE EFFECTS OF BUTYLATED HYDROXYANISOLE AGAINST BLEOMYCIN-INDUCED DIFFUSE ALVEOLAR DAMAGE IN HAMSTERS |
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