PROTECTIVE EFFECTS OF BUTYLATED HYDROXYANISOLE AGAINST BLEOMYCIN-INDUCED DIFFUSE ALVEOLAR DAMAGE IN HAMSTERS

PROTECTIVE EFFECTS OF BUTYLATED HYDROXYANISOLE AGAINST BLEOMYCIN-INDUCED DIFFUSE ALVEOLAR DAMAGE IN HAMSTERS

The effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), on bleomycin-induced diffuse alveolar damage (DAD) were investigated in male Syrian golden hamsters. Six-week-old animals were treated with a single intratracheal administration of bleomycin (BLM; 5mg/5ml/kg) or an equ...

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Veröffentlicht in:Journal of Toxicologic Pathology 1995/03/31, Vol.8(1), pp.7-14
Hauptverfasser: Enami, Tomonori, Nishikawa, Akiyoshi, Furukawa, Fumio, Mitsui, Masayuki, Yoshimura, Hiroyuki, Takahashi, Michihito, Fukushima, Shoji
Format: Artikel
Sprache:eng
Schlagworte:
BHA
BHT
Bleomycin
Lung damage
Protective effect
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Zusammenfassung:The effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), on bleomycin-induced diffuse alveolar damage (DAD) were investigated in male Syrian golden hamsters. Six-week-old animals were treated with a single intratracheal administration of bleomycin (BLM; 5mg/5ml/kg) or an equivalent volume of saline. Starting 1 day after the treatment, animals were given 1% BHA or 1% BHT in the diet or basal diet alone for 31 days. The survival rate of the BLM/BHA group (55%) was significantly higher than that of the BLM alone (15%) or BLM/BHT (15%) groups (p
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.8.7