CONCOMITANT DOSING WITH ANTAGONISTS IMPROVED TACROLIMUS (FK506)-INDUCED NEPHROTOXICITY IN RATS

FK506-induced nephrotoxicity has been reported to occur by arteriolar constriction of the renal cortex, which is induced through the production of such vasoactive factors as thromboxane A2 (TX A2), renin, etc. In the present study, we investigated whether FK506-induced nephrotoxicity is improved by...

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Veröffentlicht in:	Journal of Toxicologic Pathology 1996/09/30, Vol.9(3), pp.277-284
Hauptverfasser:	Fujii, Toshiyuki, Mitamura, Takashi, Yamada, Atsushi, Fujihira, Shiro, Ohara, Kaname, Mine, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute nephrotoxicity Concomitant dosing Rat Tacrolimus (FK506) Vasoconstriction
Online-Zugang:	Volltext
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