Imatinib in Very Elderly Patients with Chronic Myeloid Leukemia in Chronic Phase: A Retrospective Study

Background A large number of chronic myeloid leukemia (CML) patients are treated with imatinib mesylate outside of clinical trials, which may not be representative of common clinical practice. The age of CML patients enrolled within controlled clinical studies is lower with respect to patients inclu...

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Veröffentlicht in:	Drugs & aging 2013-08, Vol.30 (8), p.629-637
Hauptverfasser:	Latagliata, Roberto, Ferrero, Dario, Iurlo, Alessandra, Cavazzini, Francesco, Castagnetti, Fausto, Abruzzese, Elisabetta, Fava, Carmen, Breccia, Massimo, Annunziata, Mario, Stagno, Fabio, Tiribelli, Mario, Binotto, Gianni, Mansueto, Giovanna, Gozzini, Antonella, Russo, Sabina, Cavalli, Laura, Montefusco, Enrico, Gugliotta, Gabriele, Cedrone, Michele, Russo Rossi, Antonella, Avanzini, Paolo, Pregno, Patrizia, Mauro, Endri, Spadea, Antonio, Celesti, Francesca, Giglio, Gianfranco, Isidori, Alessandro, Crugnola, Monica, Calistri, Elisabetta, Sorà, Federica, Storti, Stefano, D’Addosio, Ada, Rege-Cambrin, Giovanna, Luciano, Luigiana, Alimena, Giuliana
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Aging Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Benzamides - administration & dosage Benzamides - adverse effects Benzamides - therapeutic use Biological and medical sciences Bone marrow Clinical medicine Clinical trials Cohort Studies Comorbidity Disease Dose-Response Relationship, Drug Drug dosages Drug Monitoring Female Follow-Up Studies Geriatrics/Gerontology Hematologic and hematopoietic diseases Hematology Humans Imatinib Mesylate Internal Medicine Italy - epidemiology Leukemia Leukemia, Myeloid, Chronic-Phase - drug therapy Leukemia, Myeloid, Chronic-Phase - epidemiology Leukemia, Myeloid, Chronic-Phase - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Medicine Medicine & Public Health Neoplasm Grading Original Research Article Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacotherapy Piperazines - administration & dosage Piperazines - adverse effects Piperazines - therapeutic use Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - therapeutic use Remission Induction Retrospective Studies Survival Analysis Toxicity
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